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Zinc acetate

Catalog Number

ACM557346

CAS

557-34-6

Structure

IUPAC Name

Zinc;diacetate

Synonyms

Diacetic acid zinc salt

Molecular Weight

183.5

Molecular Formula

C2H4O2Zn++

Canonical SMILES

CC(=O)[O-].CC(=O)[O-].[Zn+2]

InChI

InChI=1S/2C2H4O2.Zn/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;+2/p-2

InChI Key

DJWUNCQRNNEAKC-UHFFFAOYSA-L

Boiling Point

908 °C

Melting Point

83-86 °C

Flash Point

12°C

Purity

95%+

Density

1.84 g/mL at 25 °C (lit.)

Solubility

Insoluble in alkalies

Appearance

Colourless or white efflorescent crystals

Application

3-1-Dietary and medicinal applications Zinc acetate is used as a dietary supplement and in lozenges used to treat the common cold. Zinc acetate alone is thought to be a more effective treatment than zinc gluconate. Zinc acetate can also be used to treat zinc deficiencies. As an oral daily supplement it is used to inhibit the body's absorption of copper as part of the treatment for Wilson's disease. Zinc acetate is also sold as an astringent in the form of an ointment, a topical lotion; or combined with an antibiotic such as erythromycin for the topical treatment of acne. Furthermore Zinc acetate is commonly sold as a topical anti-itch ointment. 3-2-Industrial applications Industrial applications include wood preserving, manufacturing other zinc salts, polymers, manufacture of ethylene acetate, as a dye mordant, and analytical reagent. Zinc acetate is a precursor via a sol-gel route to the transparent semi conductor zinc oxide.Medicine (astringent), preserving wood, textile
dyeing (mordant and resist), zinc chromate,
laboratory reagent, cross-linking agent for polymers,
ingredient of dietary supplements (up to 1 mg
daily), feed additive, ceramic glazes.Zinc acetate has been used as an excipient in a variety of
pharmaceutical formulations including topical gels, lotions, and
solutions, and subcutaneous injections. It has also been investigated
for use in an oral controlled-release formulation for water-soluble
drugs in combination with sodium alginate and xanthan gum.
Therapeutically, zinc acetate has been used in oral capsules for
the treatment of Wilson's disease. Zinc acetate has also been
demonstrated to be effective as a spermicide in vaginal contraceptives.

Storage

Zinc acetate loses water of hydration above 101°C. Zinc acetate
should be stored in an airtight container in a cool, dry, place.

Active Content

95%

Physical State

Powder

Typical Applications

Use as antimicrobial agent, antibacterial agent, preservative.

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

Case Study

Zinc Acetate Used for the Preparation of Chitosan-ZnO Nanocomposite Films via a Green In-Situ Method

Zinc Acetate Used for the Preparation of Chitosan-ZnO Nanocomposite Films via a Green In-Situ Method Rahman, P. Mujeeb, et al. Chemical Physics Impact 8 (2024): 100492.

Zinc acetate is effectively used as a precursor for the in-situ synthesis of ZnO within chitosan matrices, enabling the preparation of nanocomposite films with enhanced mechanical performance. In this study, a green, one-pot method was employed to fabricate chitosan-ZnO films by solution casting. Chitosan was first dissolved in 5% aqueous acetic acid, followed by the incorporation of zinc acetate dihydrate. Subsequent immersion of the dried film in NaOH solution facilitated the in-situ formation of ZnO nanoparticles.
By systematically varying the concentrations of zinc acetate (0.5-2.0 g) and sodium hydroxide (0.1-0.4 M), the study established correlations between composition and mechanical properties. The films were characterized using FTIR-ATR, XRD, and SEM, confirming ZnO formation and uniform distribution within the chitosan matrix.
Mechanical strength testing revealed a significant increase in tensile strength with optimal zinc acetate and NaOH concentrations. Additionally, DFT calculations (B3LYP/LANL2DZ level) were conducted to investigate electronic structures, including HOMO-LUMO band gaps and molecular electrostatic potentials (MESP), providing theoretical validation of the experimental findings.
This work demonstrates the pivotal role of zinc acetate in generating ZnO nanophases within biopolymer systems, offering a sustainable approach to produce high-performance composite films for applications in biomedical materials, biodegradable packaging, and functional coatings.

Zinc Acetate (Zn(OAc)₂) Used for the Ultrasound-Assisted Synthesis of Xanthene Derivatives via a One-Pot Reaction

Zinc Acetate (Zn(OAc)₂) Used for the Ultrasound-Assisted Synthesis of Xanthene Derivatives via a One-Pot Reaction Sayad, Rayene, et al. RSC advances 14.34 (2024): 24585-24603.

Zinc acetate (Zn(OAc)₂) has proven to be an efficient and reusable catalyst in the green, ultrasound-assisted synthesis of xanthene derivatives-a class of compounds widely recognized for their bioactive and photophysical properties. In this study, a simple one-pot method was developed using 10 mol% Zn(OAc)₂ to catalyze the reaction between aromatic aldehydes and cyclic diketones (dimedone or 1,3-cyclohexanedione) in ethanol under ultrasonic irradiation.
Reactions were performed in standard glass tubes (25 mm × 1 mm, 20 mL volume), and monitored via thin-layer chromatography (TLC). The ultrasound energy significantly accelerated the transformation, leading to good-to-excellent yields across various substrates. Upon completion, zinc acetate was recovered by filtration and the crude product was isolated by solvent precipitation using diethyl ether/n-hexane, followed by overnight crystallization at 6 °C.
This method exemplifies a sustainable and operationally simple approach to heterocyclic synthesis, with zinc acetate serving as an effective Lewis acid catalyst. The low catalyst loading, high yields, and mild reaction conditions underscore the practical utility of Zn(OAc)₂ in organic transformations.
Overall, zinc acetate facilitates the rapid, clean synthesis of xanthene scaffolds under benign conditions, offering valuable potential for pharmaceutical and materials chemistry applications where eco-friendly and efficient methodologies are increasingly in demand.

Zinc Acetate Used for the Corrosion Inhibition of Low-Alloy Carbon Steel in Eco-Friendly Gum Arabic-Based Formulations

Zinc Acetate Used for the Corrosion Inhibition of Low-Alloy Carbon Steel in Eco-Friendly Gum Arabic-Based Formulations Danyliak, M-OM, I. M. Zin, and S. A. Korniy. Journal of Industrial and Engineering Chemistry 129 (2024): 267-277.

Zinc acetate has demonstrated significant promise as a key component in eco-friendly corrosion inhibitors for low-alloy carbon steel. In a recent study, a green inhibitor system based on zinc acetate and gum Arabic was evaluated for performance in a neutral 0.1% NaCl solution. Electrochemical impedance spectroscopy revealed that the combination reached a maximum inhibition efficiency of 98% at concentrations of 2.0 g/L for both components after 24 hours of immersion.
The corrosion inhibition mechanism is attributed to the synergistic adsorption of gum Arabic and Zn²⁺ cations on the steel surface. The hydroxyl and carboxyl groups in gum Arabic allow strong physical adsorption at anodic regions, displacing water molecules and forming a hydrophobic barrier. Concurrently, Zn²⁺ cations interact with OH⁻ anions at cathodic sites, forming zinc hydroxides that impede electron transfer. The formation of Fe²⁺-gum Arabic complexes further stabilizes the protective film on anodic regions, enhancing surface passivation.
Surface analyses confirmed the presence of a dense, adherent inhibitor layer, likely composed of Fe²⁺-Zn²⁺-gum Arabic-acetate complexes. The adsorption behavior fits well with the Langmuir isotherm model, indicating monolayer surface coverage and strong chemical interactions.
Overall, zinc acetate plays a critical role in the formation of multifunctional, self-assembling protective films, offering an effective, non-toxic corrosion inhibition strategy for carbon steel in aqueous environments.

Custom Q&A

What is the chemical formula of Zinc acetate?

The chemical formula of Zinc acetate is Zn(O2CCH3)2.

What is the boiling point of Zinc acetate?

The boiling point of Zinc acetate is 908°C.

What is the color of Zinc acetate powder?

The color of Zinc acetate powder is yellow to brown to gray-green.

What is the solubility of Zinc acetate in water?

Zinc acetate is soluble in water.

How is Zinc acetate prepared?

Zinc acetate is prepared by the reaction of acetic acid with zinc oxide followed by crystallization.

What are the safety statements associated with Zinc acetate?

The safety statements associated with Zinc acetate are 26-60-61-39-16-7.

What are the uses of Zinc acetate in industrial applications?

Zinc acetate is used in wood preservation, manufacturing other zinc salts, polymers, manufacture of ethylene acetate, as a dye mordant, and analytical reagent in industrial applications.

What is the storage condition recommended for Zinc acetate?

Zinc acetate should be stored in an airtight container in a cool, dry place.

What are the potential therapeutic applications of Zinc acetate?

Zinc acetate has been used as an excipient in pharmaceutical formulations, in oral capsules for the treatment of Wilson's disease, and as a spermicide in vaginal contraceptives.

What is a common veterinary use of Zinc acetate?

Zinc sulfate, a form of Zinc acetate, is used topically as an astringent and as a weak antiseptic for dermatologic and ophthalmic conditions in veterinary treatments.

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