Ren, H., et al. Journal of Chemical Neuroanatomy 136 (2024): 102397.
Ischemic stroke (IS) is a serious neurological condition with complex pathological mechanisms. Tetrahydropiperine (THP), a natural alkaloid, has demonstrated protective effects against various diseases, including seizures and pain. This study investigates the potential neuroprotective effects of THP in ischemic stroke and explores its underlying mechanisms.
Using network pharmacology and molecular docking techniques, we identified potential target proteins of THP for intervention in IS. Network pharmacology analysis suggested that THP's effects on IS are particularly prominent within the PI3K/Akt signaling pathway. Molecular docking results showed that THP has a strong binding affinity for proteins involved in autophagy and the PI3K/Akt/mTOR pathway.
Our results indicated that THP significantly improved behavioral outcomes, reduced cerebral infarction size, alleviated histopathological damage from ischemia, enhanced neuronal survival, and reduced ultrastructural neuronal damage (P < 0.05). Additionally, THP promoted the survival of PC-12 cells exposed to oxygen-glucose deprivation (OGD) and improved their morphological integrity (P < 0.05). Furthermore, THP increased the levels of P62, LC3-I, PI3K, P-Akt/Akt, and P-mTOR/mTOR proteins, while decreasing the levels of Atg7 and Beclin1 proteins.
What is the chemical formula for Tetrahydropiperine?
The chemical formula for Tetrahydropiperine is C17H23NO3.
What is the molecular weight of Tetrahydropiperine?
The molecular weight of Tetrahydropiperine is 289.37 g/mol.
What is the boiling point of Tetrahydropiperine?
The boiling point of Tetrahydropiperine is 261 °C at a pressure of 14 Torr.
In which solvents is Tetrahydropiperine soluble?
Tetrahydropiperine is soluble in DMF, DMSO, ethanol, and ethyl acetate.
What is the biological activity of Tetrahydropiperine?
Tetrahydropiperine inhibits the cytochrome P450 (CYP) isoform CYP1A1/aryl hydrocarbon hydroxylase.
From which plant is Tetrahydropiperine derived?
Tetrahydropiperine is derived from the near-ripe or ripe fruit of Piper nigrum L, also known as black pepper.
What is the chemical property of Tetrahydropiperine in terms of its solubility in water?
Tetrahydropiperine is insoluble in water.
What is the LogP value of Tetrahydropiperine?
The LogP value of Tetrahydropiperine is 3.674.
What is the target enzyme inhibited by Tetrahydropiperine?
Tetrahydropiperine inhibits the CYP1A1 enzyme.
What is the color and physical form of Tetrahydropiperine?
Tetrahydropiperine is a light yellow crystalline powder.
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