Diab, R., Brillault, J., Bardy, A., Gontijo, A. V. L., & Olivier, J. C. (2012). International Journal of Pharmaceutics, 436(1-2), 833-839.
This study explores the use of sucrose palmitate as a stabilizer in the formulation of inhalable rifampicin-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres (RIF-MS) for tuberculosis treatment. Traditionally, polyvinyl alcohol (PVA) has been used as a surfactant in microsphere formulations; however, in this work, sucrose palmitate, a biodegradable and biocompatible sucrose ester, was substituted to enhance the sustainability and safety of the product.
The RIF-MS were prepared using the oil-in-water (O/W) emulsion-solvent evaporation method, where a mixture of rifampicin and PLGA was emulsified in an aqueous solution of sucrose palmitate. The organic solvent was then removed by evaporation, and the microspheres were recovered through centrifugation and freeze-drying. The formulation demonstrated good stability, with sucrose palmitate effectively preventing aggregation and maintaining the integrity of the microspheres.
The incorporation of sucrose palmitate as a stabilizer not only improves the biodegradability and biocompatibility of the formulation but also ensures the controlled release of rifampicin, making it a promising candidate for the development of inhalable drug delivery systems. This study highlights the potential of sucrose palmitate in enhancing the performance of drug-loaded microspheres, particularly in the treatment of pulmonary diseases such as tuberculosis.
babu Valapa, Ravi, G. Pugazhenthi, and Vimal Katiyar. International journal of biological macromolecules 89 (2016): 70-80.
This study investigates the role of sucrose palmitate (SP) as a biofiller in poly(lactic acid) (PLA) nanocomposites, specifically focusing on its influence on hydrolytic degradation behavior. The degradation was analyzed under varying temperature and pH conditions, with significant attention to crystallinity changes, morphological alterations, and molecular weight reduction.
Results indicate that the inclusion of SP accelerates the hydrolytic degradation of PLA, particularly under basic pH and elevated temperature conditions. Thermo-gravimetric analysis confirmed a loss of thermal stability in both neat PLA and PLA-SP nanocomposites after degradation. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) revealed an increase in crystallinity as the degradation progressed, with SEM showing morphological changes, including the formation of cavities, indicative of the leaching of amorphous regions into the solvent.
The PLA-SP-5 nanocomposite exhibited a higher rate of degradation, as evidenced by a greater percentage of residual weight loss. Gel permeation chromatography (GPC) further confirmed the degradation, showing a reduction in molecular weight. These findings highlight the significant influence of SP on enhancing the degradation rate of PLA, suggesting potential applications of PLA-SP nanocomposites in biodegradable materials where controlled degradation is crucial. The study provides valuable insight into the role of sucrose palmitate in improving the hydrolytic degradation behavior of PLA-based composites.
Valapa, Ravibabu, Gopal Pugazhenthi, and Vimal Katiyar. International journal of biological macromolecules 65 (2014): 275-283.
This study explores the use of sucrose palmitate (SP) as a bio-filler in poly(lactic acid) (PLA) biocomposites, focusing on its impact on thermal degradation behavior, with potential applications in food packaging. The biocomposites were prepared with varying SP concentrations (1-10 wt%) and analyzed using thermo-gravimetric analysis (TGA) and differential scanning calorimetry (DSC).
The findings revealed that up to 5 wt% SP loading, PLA and PLA-SP composites exhibited similar thermal degradation profiles, with the degradation peak (Tmax) maintaining at 357 °C. However, at 10 wt% SP, Tmax shifted to 324 °C, suggesting that higher filler concentrations accelerate the degradation due to increased acidic sites. The DSC analysis confirmed a unimodal melting peak, indicating the α-crystalline form of PLA.
Thermal degradation kinetics, evaluated using the Flynn-Wall-Ozawa and Kissinger methods, revealed complex degradation mechanisms. The presence of SP promoted hydrolysis of the ester bonds in PLA's amorphous domains, leading to autocatalytic chain scission and the formation of oligomers with carboxylic acid terminal groups. This process resulted in a reduction in activation energy for thermal degradation.
In summary, sucrose palmitate serves as a promising green bio-filler, enhancing the thermal degradation properties of PLA, making these composites suitable for environmentally-friendly food packaging applications.
What is the product name of CAS number 26446-38-8?
The product name is Sucrose monopalmitate.
What are the synonyms for Sucrose monopalmitate?
The synonyms are Sucrose palmitate and alpha-D-Glucopyranoside, beta-D-fructofuranosyl, monohexadecanoate.
What is the molecular weight of Sucrose monopalmitate?
The molecular weight is 580.71.
What is the molecular formula of Sucrose monopalmitate?
The molecular formula is C28H52O12.
What percentage of actives does Sucrose monopalmitate contain?
Sucrose monopalmitate contains 95% actives.
In what physical state is Sucrose monopalmitate?
Sucrose monopalmitate is in a solid state.
What are typical applications of Sucrose monopalmitate?
Typical applications include use as emulsifying agent, dispersing agent, cleansing agent, and plasticizer.
How can Sucrose monopalmitate be used as an emulsifying agent?
Sucrose monopalmitate can be used to mix two or more immiscible substances.
What role does Sucrose monopalmitate play as a dispersing agent?
Sucrose monopalmitate helps to evenly distribute particles in a medium.
How does Sucrose monopalmitate function as a cleansing agent?
Sucrose monopalmitate can help to remove dirt and oils from surfaces.
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