He, Haisheng, et al. Acta Pharmaceutica Sinica B 8.1 (2018): 97-105.
Stearamine, a long-chain amine, plays a pivotal role in the synthesis of vitamin-conjugated ligands, facilitating their attachment to liposomal surfaces for enhanced drug delivery. In a recent study, stearamine was used to conjugate thiamine and niacin to create thiamine-stearamide (TH-stearamide) and niacin-stearamide, which were subsequently anchored onto the surface of liposomes. This functionalization was designed to promote the oral absorption of insulin via ligand-receptor interactions.
The synthesis of these conjugates involved reacting thiamine or niacin with stearamine under specific conditions. For TH-stearamide, the process began with the activation of thiamine using carbonyldiimidazole (CDI) as a coupling reagent, followed by reaction with stearamine in anhydrous chloroform at elevated temperatures. After purification via silica gel column chromatography and preparative high-performance liquid chromatography, the final products were successfully obtained.
These stearamine-based conjugates not only serve as efficient targeting agents but also enhance the stability and bioavailability of biomacromolecules like insulin. By employing stearamine in the synthesis of vitamin-ligand conjugates, this study highlights its importance in the development of biomimetic nanocarriers, which offer promising strategies for improving the dietary absorption and therapeutic efficacy of biomacromolecules.
Cai, Wanni, et al. Journal of Controlled Release 375 (2024): 627-642.
Stearamine (SA), a long-chain aliphatic amine, has gained significant attention in nanomedicine due to its role in the formulation of lipid-based nanoparticles (LNs). In a recent study, SA was used in combination with cholesterol to develop virus-inspired nanoparticles designed for enhanced antibiotic delivery, aiming to combat methicillin-resistant Staphylococcus aureus (MRSA) infections and promote skin wound healing.
The LNs were synthesized through an ultrasonic method, where SA and cholesterol, in a molar ratio of 7:3, were dissolved in an organic solvent and subjected to vacuum evaporation, forming a lipid film. This film was hydrated with a Tris-NaCl buffer (pH 7.4) and underwent multiple freeze-thaw cycles before being processed under ultrasound conditions to achieve a well-defined nanostructure. The resulting LNs exhibited efficient penetration into bacterial biofilms and intracellular compartments, overcoming conventional antibiotic limitations.
This study highlights the critical role of SA in forming biomimetic lipid nanocarriers, improving antibiotic efficacy by enabling controlled drug release and deeper microbial membrane infiltration. By mimicking viral nanostructures, these SA-based nanoparticles offer a promising strategy to address antimicrobial resistance and enhance therapeutic outcomes in skin wound infections.
Yu, Dejian, et al. Nano Research 14 (2021): 1210-1217.
Stearamine (SA), a long-chain aliphatic amine, has been identified as a crucial organic ligand in the synthesis of two-dimensional (2D) halide perovskites (HPs) for advanced underwater optical communication (UOC) applications. In a recent study, SA was used to construct 2D HP-based photodetectors (PDs), imparting intrinsic water resistance, ultralow noise, and superior optoelectronic properties.
SA-modified HPs exhibited a high external quantum efficiency (EQE) of 630%, a responsivity of 3.27 A·W⁻¹, and an impressive detectivity of 1.35 × 10¹² Jones. Additionally, the incorporation of SA enabled a fast rise/decay time (0.35 ms/0.54 ms), allowing precise differentiation of various light signals, including periodic, pulsed, ramp, and sine waveforms. These enhanced properties facilitated the first successful demonstration of underwater wireless transmission using ASCII codes.
The presence of SA in 2D HPs not only optimized dimensionality engineering to cover the full-spectrum UOC window but also enhanced material stability under aqueous conditions. This study establishes SA as a critical structural component in HP-based PDs, paving the way for future high-performance, water-resistant optoelectronic devices for underwater communications, remote sensing, and marine exploration.
What is the CAS number for Stearamine?
The CAS number for Stearamine is 124-30-1.
What are the synonyms for Stearamine?
The synonyms for Stearamine are 1-Octadecanamine and Octadecylamine.
What is the molecular weight of Stearamine?
The molecular weight of Stearamine is 269.51.
What is the molecular formula of Stearamine?
The molecular formula of Stearamine is C18H39N.
What is the percentage of active ingredients in Stearamine?
The active ingredients in Stearamine are 95%.
In what physical state is Stearamine found?
Stearamine is found in a solid physical state.
What are some typical applications of Stearamine?
Some typical applications of Stearamine include use as an antistatic agent, emulsifying agent, dispersing agent, corrosion inhibitor, and lubricant.
What is the chemical composition of Stearamine?
The chemical composition of Stearamine includes carbon, hydrogen, and nitrogen atoms.
How is Stearamine commonly used in industrial applications?
Stearamine is commonly used in industrial applications for its antistatic, emulsifying, dispersing, corrosion inhibiting, and lubricating properties.
What are some key properties of Stearamine that make it suitable for various applications?
Some key properties of Stearamine that make it suitable for various applications include its high level of actives, solid physical state, and versatility as an antistatic, emulsifying, dispersing, corrosion inhibiting, and lubricating agent.
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