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Sphinganine

Catalog Number

ACM764227-1

CAS

764-22-7

Structure

IUPAC Name

(2S,3R)-2-aminooctadecane-1,3-diol

Synonyms

(R-(R*,S*))-2-Aminooctadecane-1,3-diol;1,3-Octadecanediol, 2-amino-, (2S,3R)-

Molecular Weight

301.51

Molecular Formula

C18H39NO2

Canonical SMILES

CCCCCCCCCCCCCCC[C@H]([C@H](CO)N)O

InChI

OTKJDMGTUTTYMP-ZWKOTPCHSA-N

InChI Key

InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1

Boiling Point

446.0±25.0 °C

Melting Point

70-72 °C

Flash Point

223.7°C

Density

0.927±0.06g/ml

Solubility

water, 1.525 mg/L @ 25 °C (est)

Active Content

95%

Physical State

Solid

Typical Applications

Use as emulsifying agent, dispersing agent.
Use as lubricant.
Use as intermediate in organic synthesis.

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

Case Study

Sphingolipids for Hair and Scalp Health: A Bioactive Solution for Hair Loss Prevention

Sphingolipids for Hair and Scalp Health: A Bioactive Solution for Hair Loss Prevention Gerlach, Nicole, et al. Clinical, Cosmetic and Investigational Dermatology (2016): 191-203.

Sphingolipids, a class of bioactive lipids, have demonstrated significant potential in dermatological applications, particularly in promoting scalp health and hair quality. Among them, sphinganine, a key sphingolipid, has been identified as an effective inhibitor of 5-α-reductase type I, preventing the conversion of testosterone to dihydrotestosterone (DHT)-a primary factor in androgenetic alopecia.
In vitro studies confirm that sphinganine exhibits strong anti-inflammatory and antimicrobial properties, which contribute to a healthier scalp environment. Its ability to stimulate the expression of antimicrobial peptide HBD2 suggests a role in enhancing the scalp's natural defense mechanisms. Ex vivo studies further indicate its high bioavailability, making it suitable for topical applications.
Clinical trials demonstrate that topical application of sphinganine significantly reduces non-illness-related hair loss while improving overall hair density, strength, and scalp hydration. These effects are attributed to its dual action-direct inhibition of DHT formation and enhancement of scalp barrier function.
The growing body of evidence supports sphingolipids, particularly sphinganine, as promising active ingredients in hair care formulations. Their ability to modulate keratinocyte differentiation, ceramide production, and scalp microbiome balance underscores their potential as natural alternatives to conventional hair loss treatments. These findings position sphinganine as an innovative solution for the development of advanced, scalp-friendly, and effective anti-hair loss products.

Custom Q&A

What is the IUPAC name of Sphinganine?

The IUPAC name of Sphinganine is (2S,3R)-2-aminooctadecane-1,3-diol.

What is the molecular weight of Sphinganine?

The molecular weight of Sphinganine is 301.51.

What is the molecular formula of Sphinganine?

The molecular formula of Sphinganine is C18H39NO2.

What is the boiling point of Sphinganine?

The boiling point of Sphinganine is 446.0±25.0°C.

What is the melting point of Sphinganine?

The melting point of Sphinganine is 70-72°C.

What is the density of Sphinganine?

The density of Sphinganine is 0.927±0.06g/ml.

What are some synonyms of Sphinganine?

Some synonyms of Sphinganine include (R-(R*,S*))-2-Aminooctadecane-1,3-diol and 1,3-Octadecanediol, 2-amino-, (2S,3R)-.

What are the typical applications of Sphinganine?

The typical applications of Sphinganine include use as an emulsifying agent, dispersing agent, lubricant, and intermediate in organic synthesis.

What is the InChI key for Sphinganine?

The InChI key for Sphinganine is InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1.

What percentage of actives does Sphinganine contain?

Sphinganine contains 95% actives.

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