Fornasier, Marco, et al. Journal of Colloid and Interface Science 677 (2025): 842-852.
Span 80 (Sorbitan monooleate), a nonionic surfactant, plays a crucial role in stabilizing monoolein-based cubosomes and hexosomes for photodynamic therapy (PDT) in skin metastatic melanoma treatment. In this study, Span 80 was employed in combination with sodium taurocholate (TC) to formulate bicontinuous cubic or hexagonal nanoparticles. These nanoparticles were optimized through small-angle X-ray scattering and cryo-transmission electron microscopy, which confirmed their structure depending on the ratio of TC to Span 80.
The addition of Span 80, in conjunction with taurocholate, enhanced the stability and biocompatibility of the nanoparticles, facilitating efficient dermal and transdermal drug delivery. This was particularly important in overcoming the skin's stratum corneum barrier. The nanoparticles were co-loaded with Chlorin e6 (Ce6), a photosensitizer, and coenzyme QH (CoQH), an antioxidant, both of which demonstrated high encapsulation efficiency. In vitro studies on human melanoma cells (Me45) showed that the co-loaded formulations exhibited notable photodynamic activity, paving the way for their potential use in skin cancer treatments.
These findings highlight the essential role of Span 80 in the formulation of non-lamellar lipid nanoparticles, providing an effective platform for PDT in skin cancer therapy with enhanced biocompatibility and drug encapsulation.
Deng, Henghui, et al. Chemical Engineering Journal 446 (2022): 137124.
Sorbitan monooleate (SP), a renewable polyol, has emerged as a key component in the development of bio-based waterborne polyurethane (WPU) with enhanced mechanical, UV-resistant, and corrosion-resistant properties. In this study, SP was used in combination with castor oil to design a series of bio-based WPUs. The effect of varying the hydroxyl ratios of SP and castor oil on the chemical structures and properties of the resulting WPU dispersions and films was thoroughly examined.
The incorporation of SP into the WPU network facilitated the formation of intermolecular hydrogen bonds and rigid furan rings, resulting in high crosslinking densities. These features significantly contributed to the WPU films' impressive mechanical properties, including a tensile strength of 26.32 MPa and a glass transition temperature (Tg) of 69.40 °C. Furthermore, the WPU films exhibited excellent UV resistance, effectively blocking radiation in the 200-400 nm range, and demonstrated strong corrosion protection, maintaining high efficiency (95.39%) after six months of outdoor exposure.
These findings highlight SP's potential as a bio-based polyol in the design of sustainable WPUs with superior UV and corrosion resistance, making it an excellent candidate for applications in protective coatings and high-performance materials.
Yeh, Carol Kuei-Jyum, Su-Lan Peng, and I-Yuang Hsu. Chemosphere 49.4 (2002): 421-430.
Sorbitan monooleate (Span 80), an oil-philic surfactant, plays a critical role in enhancing the recovery of tetrachloroethylene (PCE) in flushing systems when used in combination with non-ionic surfactant Tween 80. This study explores the impact of the Tween 80-Span 80 co-surfactant system on PCE solubilization and recovery from laboratory columns packed with silica and aquifer sand.
The co-surfactant mixture (Tween 80 + Span 80, 4:1 ratio) significantly improved the solubilization capacity and hydrophobic properties of the flushing solution, achieving an 84% increase in the molar solubilization ratio (MSR) and a 9% increase in the affinity between micelles and PCE. Compared to flushing with 1% Tween 80 alone, the co-surfactant solution enhanced PCE recovery by 3% and 6% for silica and aquifer sand, respectively, per pore volume (PV).
Batch solubility tests and column flushing experiments both indicated that micellar dissolution, characteristic of the Winsor type I system, was the primary mechanism for PCE removal when using the co-surfactant solution. The addition of Span 80 not only altered the distribution of Tween 80 in the system but also enhanced the overall PCE recovery, confirming the importance of Span 80 in optimizing solubilization and improving the efficiency of soil and groundwater remediation processes.
What is the product name of CAS number 1338-43-8?
The product name is Sorbitan oleate.
What are some synonyms for Sorbitan oleate?
Some synonyms for Sorbitan oleate are Span 80, Sorbitan monooleate, and Anhydrosorbitol monooleate.
What is the molecular weight of Sorbitan oleate?
The molecular weight of Sorbitan oleate is 428.6.
What is the molecular formula of Sorbitan oleate?
The molecular formula of Sorbitan oleate is C24H44O6.
What is the IUPAC name of Sorbitan oleate?
The IUPAC name of Sorbitan oleate is [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (Z)-octadec-9-enoate.
What is the boiling point of Sorbitan oleate?
The boiling point of Sorbitan oleate is 463 °C.
What is the density of Sorbitan oleate?
The density of Sorbitan oleate is 0.986g/ml.
What are the typical applications of Sorbitan oleate?
The typical application of Sorbitan oleate is as an emulsifying agent.
What is the percentage of actives in Sorbitan oleate?
The percentage of actives in Sorbitan oleate is 95%.
What is the Hydrophilic-Lipophilic Balance (HLB) of Sorbitan oleate?
The Hydrophilic-Lipophilic Balance (HLB) of Sorbitan oleate is 4.3.
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