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Sodium Lauroyl Sarcosine

Catalog Number

ACM137166-1

CAS

137-16-6

Structure

IUPAC Name

Sodium;2-[dodecanoyl(methyl)amino]acetate

Synonyms

Sodium lauroyl sarcosinate

Molecular Weight

293.38

Molecular Formula

C15H28NNaO3

Canonical SMILES

CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]

InChI

KSAVQLQVUXSOCR-UHFFFAOYSA-M

InChI Key

InChI=1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19;/h3-13H2,1-2H3,(H,18,19);/q;+1/p-1

Melting Point

46 °C

Flash Point

267 °C

Density

1.033g/ml

Active Content

90%

7-9

Physical State

Solid

Typical Applications

Use as cleansing agent.
Use as dispersing agent, emulsifying agent.

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

Case Study

Sodium N-Lauroylsarcosinate Used for the Flotation Separation of Hemimorphite from Quartz

Sodium N-Lauroylsarcosinate Used for the Flotation Separation of Hemimorphite from Quartz Jia, Kai, et al. Minerals Engineering 198 (2023): 108073.

Sodium N-lauroylsarcosinate (LS), a biodegradable biosurfactant, has emerged as an effective green collector for the selective flotation separation of hemimorphite from quartz. This study investigates the flotation performance of LS and compares it with sodium oleate (NaOL), a commonly used flotation reagent. The flotation tests revealed that LS exhibited superior selectivity for hemimorphite, achieving successful separation at a concentration of 3.4 × 10⁻⁴ mol/L and a neutral pH of 7, with a Gaudin's selectivity index (SI) of 67.58. In contrast, NaOL's SI remained low across the pH range.
The mechanism of LS adsorption on the mineral surfaces was elucidated through a combination of surface tension, contact angle measurements, zeta potential analysis, and advanced spectroscopic techniques. ATR-FTIR and XPS analysis revealed that LS adsorbed selectively on the hemimorphite surface, likely via chemisorption involving the carboxyl group interacting with Zn sites, forming C(=O)-O-Zn linkages. Density functional theory (DFT) calculations confirmed this interaction, showing bidentate bonding structures between LS and the hemimorphite surface.
This study underscores the potential of LS for more efficient and selective flotation separation in mineral processing, positioning it as a promising green alternative to traditional collectors.

Sodium N-Lauroylsarcosinate Used for the Preparation of Oil-in-Water Microemulsions for α-Tocopherol Encapsulation

Sodium N-Lauroylsarcosinate Used for the Preparation of Oil-in-Water Microemulsions for α-Tocopherol Encapsulation Manyala, Dhana Lakshmi, Moulie Ghosh, and Sridhar Dalai. Journal of Molecular Liquids 384 (2023): 122323.

Sodium N-lauroylsarcosinate (SNLS), an amino acid-derived biodegradable surfactant, has been effectively utilized in the preparation of oil-in-water (o/w) microemulsions (MEs) for the encapsulation and delivery of hydrophobic bioactive compounds such as α-tocopherol. This innovative application addresses the critical challenge of formulating nanocarriers from biocompatible materials at low surfactant concentrations while maintaining structural stability.
In this study, SNLS served as the primary surfactant in o/w MEs, significantly enhancing the solubility of α-tocopherol from 0.1% in a 10% SNLS solution to 0.2% and 0.8% in MEs without and with a co-surfactant (butanol), respectively. Optimization of ME composition was guided by conductivity, viscosity, and encapsulation efficiency studies, with the SNLS:butanol ratio set at 1:1. Dynamic light scattering revealed that co-surfactant inclusion reduced droplet size from 304 nm to 199 nm and improved colloidal stability, as supported by low PDI and negative zeta potential.
High-resolution TEM confirmed spherical ME morphology, and FTIR spectra indicated molecular interactions between SNLS and α-tocopherol. Antioxidant activity was preserved post-encapsulation, with an IC₅₀ of 9 mg/mL, while contact angle analysis demonstrated superior wettability on hydrophobic surfaces.
These findings underscore the potential of SNLS-based MEs as efficient, green nanocarriers for lipophilic antioxidant delivery in pharmaceutical and cosmetic formulations.

Sodium N-Lauroylsarcosinate Used for the Selective Flotation of Fluorite from Scheelite Without a Depressant

Sodium N-Lauroylsarcosinate Used for the Selective Flotation of Fluorite from Scheelite Without a Depressant Gao, Zhiyong, et al. Journal of Molecular Liquids 318 (2020): 114031.

Sodium N-lauroylsarcosinate (SNLS), a biodegradable and cost-effective surfactant, has emerged as a promising collector in mineral flotation. In a recent study, SNLS was employed for the selective flotation of fluorite from scheelite-two calcium-containing minerals with similar surface properties that pose significant challenges in separation.
Flotation experiments using binary mixtures of fluorite and scheelite (1:1 mass ratio) demonstrated that SNLS, at a low dosage of 1.1 × 10⁻⁵ mol/L and pH 9.0, exhibited strong selectivity toward fluorite without the need for an additional depressant. Zeta potential measurements revealed that SNLS molecules, negatively charged at pH 9.0, preferentially adsorbed onto the more positively charged fluorite surfaces via electrostatic interactions.
Further surface analyses using FTIR, XPS, and DFT calculations confirmed that the three active oxygen atoms in SNLS form stable chemical bonds with surface Ca²⁺ ions on fluorite. The stronger interaction with fluorite, compared to scheelite, was attributed to the higher surface Ca density and reactivity of fluorite, facilitating Ca-NLS complex formation.
These findings highlight SNLS as a green, efficient, and selective flotation reagent for the industrial separation of fluorite from scheelite, offering a viable alternative to traditional collectors and depressants in mineral processing.

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