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Sodium isethionate

Catalog Number

ACM1562001-4

CAS

1562-00-1

Structure

IUPAC Name

Sodium; 2-hydroxyethanesulfonate

Synonyms

Sodiumbeta-hydroxyethanesulfonate

Molecular Weight

148.11

Molecular Formula

C2H5NaO4S

Canonical SMILES

C(CS(=O)(=O)[O-])O.[Na+]

InChI

InChI=1S/C2H6O4S.Na/c3-1-2-7(4,5)6;/h3H,1-2H2,(H,4,5,6);/q;+1/p-1

InChI Key

LADXKQRVAFSPTR-UHFFFAOYSA-M

Melting Point

191-194 °C(lit.)

Purity

98%

Density

1.625 g/cm³

Solubility

Soluble in water

Appearance

White fine powder

Storage

Store below +30 °C

Active Content

90%

Physical State

Solid

Typical Applications

Use as intermediates in organic synthesis.

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

Case Study

Sodium Isethionate Used for the Synthesis and Purification of Sodium Lauroyl Isethionate for Personal Care Applications

Sodium Isethionate Used for the Synthesis and Purification of Sodium Lauroyl Isethionate for Personal Care Applications Jeraal, M. I., Roberts, K. J., McRobbie, I., & Harbottle, D. (2018). ACS Sustainable Chemistry & Engineering, 6(2), 2667-2675.

Sodium isethionate plays a pivotal role in the synthesis of sodium lauroyl isethionate (SLI), a mild and biodegradable anionic surfactant widely employed in personal care formulations. In a recent study, SLI was synthesized via a solvent-free, chlorine- and catalyst-free esterification of sodium isethionate with lauric acid. This sustainable approach improves process safety and throughput, aligning with green chemistry principles.
The resulting crude product was purified through repeated recrystallization in methanol to achieve a high purity of 98%. Physicochemical characterization of the purified SLI revealed valuable insights into its performance profile. Surface tension analysis showed a reduced critical micelle concentration (CMC) of 5.4 mM and a low equilibrium surface tension of 38 mN/m at 20 °C, both superior to previously reported commercial benchmarks. These improvements highlight the performance advantage of using purified isethionate-based surfactants in formulations.
Thermal and humidity stability were confirmed via thermogravimetric analysis (decomposition onset: 330 °C) and dynamic vapor sorption (reversible 2.3% mass gain at 87% RH), respectively. Turbidimetric solubility profiling indicated a well-defined crystallization behavior and metastable zone width.
In summary, sodium isethionate is used for the synthesis of high-purity sodium lauroyl isethionate, enabling the development of high-performance, eco-friendly surfactants. This work provides critical insights for manufacturers seeking to improve the purity, functionality, and sustainability of personal care ingredients derived from bio-based sources.

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