Benzaria, Amal, et al. Food research international 51.2 (2013): 679-692.
Retinyl acetate (RAC) was encapsulated in two different carrier systems: a whey protein-stabilized submicron emulsion and RAC-micelles using polysorbate 80 (Tween® 80) as an emulsifier. The submicron emulsion was prepared by ultra-high-pressure homogenization (UHPH) at 200 MPa, employing a two-pass homogenization process with an initial temperature of 24 °C. Peanut oil-in-water emulsions were stabilized with whey proteins, ensuring nanoscale droplet formation.
For comparison, RAC-micelles were synthesized at atmospheric pressure following a modified method from Anwar et al. (2006). Tween® 80 was dissolved in acetone at 12 mg/mL, while RAC was separately dissolved in absolute ethanol at 0.15 mg/mL. A 20 μL aliquot of the Tween® 80 solution was mixed with 11.56 mL of the RAC solution, and the resulting ethanol-acetone mixture was evaporated under a nitrogen stream. The remaining residue was re-suspended in 12 mL of phenol red-free DMEM, yielding a final concentration of 15.3 μmol/L Tween® 80 and 440 μmol/L RAC.
Both formulations were evaluated in TC7-cell monolayers for their effects on cellular integrity, viability, and membrane permeability. Cellular uptake studies using confocal microscopy confirmed RAC internalization, with HPLC analysis revealing intracellular RAC conversion to retinol. While RAC-micelles exhibited higher bioaccessibility, the whey protein-stabilized emulsion provided superior physical stability, making it a promising alternative for long-term delivery applications.
Blayo, Claire, et al. Food research international 66 (2014): 167-179.
Retinyl acetate (RAC), a lipophilic vitamin A derivative, was incorporated into whey protein isolate (WPI) and native phosphocaseins (PC) using advanced pressure-assisted processing techniques to enhance its stability and bioavailability. The study investigated three distinct methods: ultra-high-pressure homogenization (UHPH) at 300 MPa, isostatic high-pressure (HP) treatment at 300 MPa, and continuous short-time thermal treatment (STTT) at 73 °C for 4 s.
RAC solutions (40-140 mmol/L) were freshly prepared in absolute ethanol and subsequently mixed with WPI or PC dispersions under gentle stirring at 67 rpm for 5 min, ensuring homogeneity while minimizing light exposure. The final dispersions maintained molar RAC-to-protein ratios of 1:10 for β-lactoglobulin (β-Lg) and 1:5 for phosphocaseins, with ethanol concentrations kept below 2% (v/v). Absorbance at 325 nm was used to quantify RAC concentrations, applying a molar extinction coefficient of 52,500 L mol-1 cm-1.
Control samples, prepared without RAC, underwent identical processing. Structural changes induced by high-pressure and thermal treatments facilitated improved RAC-protein interactions, potentially enhancing RAC encapsulation efficiency and stability. These findings highlight the potential of pressure-assisted technologies in optimizing protein-based delivery systems for bioactive compounds, particularly in functional food and pharmaceutical formulations.
Arayachukeat, S., Wanichwecharungruang, S. P., & Tree-Udom, T. (2011). International journal of pharmaceutics, 404(1-2), 281-288.
Retinyl acetate (RA), a widely used vitamin A derivative, is highly sensitive to environmental factors such as light and oxygen. To improve its stability and bioavailability, RA-loaded polymeric nanoparticles (NPs) were prepared using ethyl cellulose (EC) and poly(ethylene glycol)-4-methoxycinnamoylphthaloylchitosan (PCPLC) as carriers.
RA-loaded PCPLC NPs were synthesized via solvent displacement and dialysis under lightproof conditions. Different polymer-to-RA weight ratios (1:1, 1.5:1, and 3:1) were tested, with PCPLC dissolved in DMSO and dialyzed against water using a regenerated cellulose membrane. The resulting NPs were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential analysis. Aqueous suspensions were further freeze-dried to obtain dry NP formulations. RA-loaded EC NPs were prepared using a similar approach, replacing PCPLC with EC and DMSO with acetone.
The study demonstrated that nanoparticle encapsulation effectively improved the physicochemical stability of RA. The size, morphology, and surface charge of the NPs varied depending on the polymer type and formulation ratio, influencing their dispersion and potential for controlled release. These findings suggest that polymeric nanoparticles offer a promising strategy for enhancing the delivery and efficacy of RA in pharmaceutical and cosmetic applications.
What is the product name for the chemical compound with CAS number 127-47-9?
The product name is Retinyl acetate.
What is another name for Retinyl acetate?
Another name for Retinyl acetate is Vitamin A acetate.
What is the molecular weight of Retinyl acetate?
The molecular weight of Retinyl acetate is 328.49.
What is the molecular formula of Retinyl acetate?
The molecular formula of Retinyl acetate is C22H32O2.
What is the percentage of actives in Retinyl acetate?
The percentage of actives in Retinyl acetate is 95%.
In what physical state does Retinyl acetate exist?
Retinyl acetate exists as a solid.
What is the typical application of Retinyl acetate?
The typical application of Retinyl acetate is as an antioxidant.
What is the chemical structure of Retinyl acetate?
The chemical structure of Retinyl acetate is C22H32O2.
What role does Retinyl acetate play in skincare products?
Retinyl acetate is commonly used in skincare products for its antioxidant properties.
How is Retinyl acetate typically sourced or produced?
Retinyl acetate is typically sourced or produced synthetically for use in various applications.
CONNECT WITH US
Interested in our Services & Products ?
Need detailed information?
Terms & Conditions
Privacy Policy | Cookie Policy | Copyright © 2025 Alfa Chemistry. All rights reserved.
PAGE TOP
