Quinidine

• Catalog Number: ACM56542
• CAS: 56-54-2
• IUPAC Name: (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
• Synonyms: (8R,9S)-6'-Methoxycinchonan-9-ol
• Molecular Weight: 324.4
• Molecular Formula: C20H24N2O2
• Canonical SMILES: COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1
• InChI: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
• InChI Key: LOUPRKONTZGTKE-LHHVKLHASA-N
• Melting Point: 168-172 °C
• Purity: 98%+
• Solubility: less than 0.1 mg/mL at 64° F (NTP, 1992);8.15e-04 M;1 g /quinidine/ dissolves in about 36 ml alcohol, 56 ml ether, 1.6 ml chloroform; very soluble in methanol; practically insoluble in petroleum ether.;Soluble in benzene;In water, 140 mg/l @ 25 deg C;3.34e-01 g/L;>48.7 [ug/mL]
• Appearance: Powder or Crystals
• Application: Quinidine occurs in cinchona bark to about0.25-0.3% and also in cuprea bark. It is present in quinine sulfate mother liquor. Itis formed by isomerization of quinine. Itis used in the prevention of certain cardiacarrhythmias.Primary indications for the use of quinidine include (1) abolition of premature complexes that have an atrial, A-V junctional, or ventricular origin; (2) restoration of normal sinus rhythm in atrial flutter and atrial fibrillation after controlling the ventricular rate with digitalis; (3) maintenance of normal sinus rhythm after electrical conversion of atrial arrhythmias; (4) prophylaxis against arrhythmias associated with electrical countershock; (5) termination of ventricular tachycardia; and (6) suppression of repetitive tachycardia associated with Wolff- Parkinson-White (WPW) syndrome. Although quinidine often is successful in producing normal sinus rhythm, its administration in the presence of a rapid atrial rate (flutter and possibly atrial fibrillation) can lead to a further and dangerous increase in the ventricular rate secondary to inhibition of basal vagal tone upon the A-V node. For this reason, digitalis should be used before quinidine when one is attempting to convert atrial flutter or atrial fibrillation to normal sinus rhythm.
• Storage: Keep cold.
• Active Content: 95%
• Physical State: Powder
• Typical Applications: Use as pharmaceutical ingredient(antiarrhythmic drug) (For reference only).