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Propylene glycol caprylate

Catalog Number

ACM31565125-1

CAS

31565-12-5

Structure

IUPAC Name

2-Hydroxypropyl octanoate

Synonyms

Propylene glycol monocaprylate;Propylene glycol monooctanoate;Octanoic acid, monoester with 1,2-propanediol;Propylene glycol octanoate

Molecular Weight

202.29

Molecular Formula

C11H22O3

Canonical SMILES

CCCCCCCC(=O)OCC(C)O

InChI

GHHURQMJLARIDK-UHFFFAOYSA-N

InChI Key

InChI=1S/C11H22O3/c1-3-4-5-6-7-8-11(13)14-9-10(2)12/h10,12H,3-9H2,1-2H3

Active Content

95%

Physical State

Liquid

Typical Applications

Use as lubricant.
Use as dispersing agent, emulsion stabilizer.

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

Case Study

Propylene Glycol Monocaprylate Used for the Preparation of pH-Controlled SMEDDS for Simvastatin Delivery

Propylene Glycol Monocaprylate Used for the Preparation of pH-Controlled SMEDDS for Simvastatin Delivery Ćetković, Zora, Sandra Cvijić, and Dragana Vasiljević. Journal of Drug Delivery Science and Technology 53 (2019): 101222.

Propylene glycol monocaprylate was employed as a key oil component in the formulation of self-microemulsifying drug delivery systems (SMEDDS) designed for the pH-controlled oral delivery of simvastatin (SV). These lipid-based systems aim to enhance the bioavailability of SV by targeting its release to the distal ileum.
In the formulation process, propylene glycol monocaprylate was blended with other lipid excipients such as polyethylene glycol 300 oleic glycerides and propylene glycol monolaurate, serving as the lipid phase. The surfactant, PEG 400 caprylic/capric glycerides, and the co-surfactant, PEG-15 hydroxystearate, were incorporated to facilitate rapid emulsification and stability.
Following optimization of the liquid SMEDDS, the system was combined with pH-sensitive polymethacrylate polymers to produce gel-like, viscoelastic matrices capable of modulating SV release according to the gastrointestinal pH profile. These hybrid systems demonstrated excellent emulsification properties, robustness to dilution, and nanoscale droplet sizes.
In vitro dissolution studies confirmed the sustained release of SV in the target pH range corresponding to the distal ileum, aligning with the absorption window of the drug. Propylene glycol monocaprylate contributed significantly to the formulation's lipid solubilization capacity, confirming its utility in oral controlled-release drug delivery strategies.

Custom Q&A

What is the product name of the chemical with CAS number 31565-12-5?

The product name is Propylene glycol caprylate.

What are some synonyms for Propylene glycol caprylate?

Some synonyms include Propylene glycol monocaprylate, Propylene glycol monooctanoate, and Octanoic acid, monoester with 1,2-propanediol.

What is the IUPAC name of Propylene glycol caprylate?

The IUPAC name is 2-Hydroxypropyl octanoate.

What is the molecular weight of Propylene glycol caprylate?

The molecular weight is 202.29.

What is the molecular formula of Propylene glycol caprylate?

The molecular formula is C11H22O3.

What is the SMILES notation for Propylene glycol caprylate?

The SMILES notation is CCCCCCCC(=O)OCC(C)O.

What is the InChI representation for Propylene glycol caprylate?

The InChI representation is GHHURQMJLARIDK-UHFFFAOYSA-N.

What percentage of actives does Propylene glycol caprylate contain?

It contains 95% actives.

What is the physical state of Propylene glycol caprylate?

It is in liquid form.

What are some typical applications of Propylene glycol caprylate?

It is used as a lubricant and as a dispersing agent and emulsion stabilizer.

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