Potassium azeloyl diglycinate

Catalog Number

ACM477773674-1

CAS

477773-67-4

Structure

IUPAC Name

Potassium;2-[[9-(carboxymethylamino)-9-oxononanoyl]amino]acetate

Synonyms

Potassium hydrogen heptylenedicarboxamidodiacetate

Molecular Weight

340.41

Molecular Formula

C13H21KN2O6

Canonical SMILES

C(CCCC(=O)NCC(=O)O)CCCC(=O)NCC(=O)[O-].[K+]

InChI

HOZMBDKPRFLCKN-UHFFFAOYSA-M

InChI Key

InChI=1S/C13H22N2O6.K/c16-10(14-8-12(18)19)6-4-2-1-3-5-7-11(17)15-9-13(20)21;/h1-9H2,(H,14,16)(H,15,17)(H,18,19)(H,20,21);/q;+1/p-1

Active Content

95%

Physical State

Solid

Typical Applications

Use as dispersing agent, emulsifying agent.
Use as cleansing agent.

MSDS

Download MSDS

COA

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Spec Sheet

Download Spec Sheet

Case Study

Potassium Azeloyl Diglycinate Used for the Preparation of a Stable Anti-Aging Cream with Regenerative and Moisturizing Properties

Potassium Azeloyl Diglycinate Used for the Preparation of a Stable Anti-Aging Cream with Regenerative and Moisturizing Properties Rohmani, S., Dinda, K. E., & Ainurofiq, A. (2021, May). In Journal of Physics: Conference Series (Vol. 1912, No. 1, p. 012041). IOP Publishing.

Potassium Azeloyl Diglycinate has been utilized as a multifunctional active in the formulation of an oil-in-water type anti-aging cream aimed at enhancing skin hydration and regeneration. In this study, creams containing varying concentrations (0%, 3%, 5%, and 7%) of Potassium Azeloyl Diglycinate were prepared and evaluated for stability and biological efficacy.
The formulation process began by preparing the oil phase-comprising vaselinum album, stearic acid, mineral oil, paraffin liquid, glycerin, and Nipasol-heated to 70 °C and mixed until homogeneous. Simultaneously, the water phase was prepared using Aqua Dest, pre-heated to 70 °C, with PGA, TEA, Nipagin, and Potassium Azeloyl Diglycinate added in sequence and stirred to uniformity. The water phase was gradually combined with the oil phase under continuous manual stirring. After addition of vanilla essence and further cooling to 35 °C, a homogeneous cream of thick consistency was obtained.
Among all formulations, the 5% Potassium Azeloyl Diglycinate cream (F2) showed the best physicochemical stability. In vivo tests revealed its superior ability to regenerate erythema-damaged mouse skin and improve skin hydration in human volunteers. Although its antioxidant activity was classified as very weak (IC₅₀ = 83,946.587 ppm), the compound significantly contributed to skin recovery and moisture retention, affirming its potential as an effective active in anti-aging skincare formulations.

Potassium Azeloyl Diglycinate Used for the Preparation of Antibiotic-Enhanced Hydrogels for Acne Treatment

Potassium Azeloyl Diglycinate Used for the Preparation of Antibiotic-Enhanced Hydrogels for Acne Treatment Kostrzębska, Agnieszka, Adam Junka, and Witold Musiał. International Journal of Molecular Sciences 26.11 (2025): 5239.

Potassium Azeloyl Diglycinate (also known as azeloglycine) was utilized in the preparation of hydrophilic hydrogel formulations designed to enhance the topical delivery and stability of antibiotics-tetracycline and chlortetracycline-for the treatment of acne vulgaris. Twelve formulations (100 g each) were developed with either 0.2 g of tetracycline (T) or chlortetracycline (Ch), with half supplemented by 2.0 g of azeloglycine (A) and the remainder acting as controls (B). Each antibiotic group was further divided by pH: mildly acidic (pH ≈ 6.6), neutral (pH ≈ 7.3), and mildly alkaline (pH ≈ 8.2), adjusted by AMPD concentration.
The incorporation of Potassium Azeloyl Diglycinate significantly improved the physicochemical stability of tetracycline, especially under alkaline conditions. It also enhanced the rheological behavior of the hydrogels, improving application consistency and promoting active ingredient penetration into model sebum. Microbiological assays demonstrated strong antimicrobial activity of all formulations against Staphylococcus aureus, with azeloglycine-enriched hydrogels reducing biofilm mass more effectively than their counterparts.
Importantly, none of the formulations exhibited toxicity in Galleria mellonella larvae, supporting their safety for topical use. This study highlights Potassium Azeloyl Diglycinate as a valuable multifunctional additive that not only stabilizes labile antibiotics but also contributes synergistically to anti-acne efficacy through improved delivery and sebum-targeting properties.

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