Mariadoss, Arokia Vijaya Anand, et al. International journal of biological macromolecules 130 (2019): 997-1008.
Phloretin (PHL), a hydrophobic phytochemical with potent anticancer properties, suffers from poor solubility and low bioavailability, limiting its therapeutic potential. To overcome these challenges, researchers have developed phloretin-loaded chitosan nanoparticles (PhCsNPs) as a stable and biocompatible drug delivery system.
PhCsNPs were synthesized using a modified ionotropic gelation technique, where sodium tripolyphosphate (TPP) was added dropwise into a chitosan solution containing PHL under controlled stirring conditions. The nanoparticles were formed without aggregation and purified through centrifugation and ethanol washing. This encapsulation strategy significantly improved PHL stability and dispersion in aqueous media.
Preliminary studies suggest that PhCsNPs enhance cellular uptake and controlled drug release, making them a promising nanocarrier for cancer therapy. Future investigations should focus on their pharmacokinetics and in vivo efficacy to validate their therapeutic applicability.
Zhao, Ting, et al. International Journal of Biological Macromolecules 280 (2024): 135724.
Diabetic wounds are prone to infection and delayed healing due to chronic hyperglycemia-induced immune dysfunction. Phloretin (PHL), a natural flavonoid with antibacterial and anti-inflammatory properties, has shown promise in addressing these challenges. However, its poor solubility limits therapeutic application. To enhance its bioavailability, researchers developed a phloretin-γ-cyclodextrin (PHL@CD) complex for incorporation into advanced wound dressings.
The PHL@CD complex was synthesized via an inclusion process in which PHL was dissolved in ethanol and mixed with γ-cyclodextrin in deionized water under controlled stirring and temperature conditions. The resulting complex was lyophilized into a stable powdered form and integrated into nanofiber wound dressings composed of polycaprolactone and silk protein. These dressings provided an optimal wound-healing environment by facilitating nutrient transport and gas exchange while delivering PHL in a controlled manner.
This innovative approach improves the therapeutic potential of phloretin, offering a promising strategy for infection control and accelerated wound repair in diabetic patients.
Li, Jiawei, et al. Chemical Engineering Journal 490 (2024): 151506.
The urgent demand for sustainable polymer materials has led to the development of bio-based waterborne polyurethane (WPU) using renewable plant-derived compounds. Phloretin (PRT), a naturally occurring flavonoid, was successfully incorporated into a novel cashew shell oil-based WPU system as a polyol component. This approach enhanced the polymer network's structural integrity, achieving superior mechanical properties, water resistance, and UV stability.
In this synthesis, phloretin was introduced alongside sorbitan monooleate-based siloxane (MSP) into the polyurethane skeleton via molecular structure design. The prepolymerization process involved the reaction of isophorone diisocyanate (IPDI), dimethylolbutanoic acid (DMBA), cashew shell oil-based polyols, and PRT under controlled conditions. The incorporation of PRT was systematically adjusted by varying its hydroxyl molar ratio to optimize the WPU network. Upon completion of the prepolymer stage, MSP was added as a post-chain extender, followed by neutralization and emulsification to yield stable WPU dispersions.
The resulting phloretin-modified WPUs exhibited high bio-based content (91%) and demonstrated excellent toughness, transparency, and corrosion resistance. This study highlights phloretin's potential as a multifunctional polyol in green polyurethane chemistry, promoting sustainable polymer innovations.
What is the CAS number for Phloretin?
The CAS number for Phloretin is 60-82-2.
What is the molecular weight of Phloretin?
The molecular weight of Phloretin is 274.26.
What is the molecular formula of Phloretin?
The molecular formula of Phloretin is C15H14O5.
What is the boiling point of Phloretin?
The boiling point of Phloretin is predicted to be 534.4 °C at 760 mmHg.
What is the melting point of Phloretin?
The melting point of Phloretin is 260-262°C.
What is the purity of Phloretin?
The purity of Phloretin is 98%.
What is the density of Phloretin?
The density of Phloretin is 1.429 g/cm³.
What is the appearance of Phloretin?
The appearance of Phloretin is a crystalline solid.
What are the typical applications of Phloretin?
Phloretin is typically used as an antioxidant.
What is the percentage of actives in Phloretin?
Phloretin contains 95% actives.
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