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Shams, Soroush, et al. International Journal of Biological Macromolecules 306 (2025): 141463.
Niacinamide (NA) has been incorporated into electrospun poly(lactic acid) (PLA) and hyaluronic acid (HA) nanofibrous mats to evaluate its potential in wound dressing applications. The experimental procedure can be summarized as follows:
1. Optimization of PLA concentration: PLA solutions ranging from 4 to 12 wt% were electrospun. Smooth, bead-free fibers were obtained at 8 wt%, with an average fiber diameter of 632 nm.
2. Optimization of HA concentration: HA was tested between 0.25 and 1 wt%. Only the 1 wt% HA solution produced bead-free fibers, with a smaller average diameter of 234 nm.
3. Preparation of PLA-HA hybrid mats: Using a dual-syringe electrospinning setup, PLA and HA solutions were simultaneously electrospun onto a cylindrical collector positioned 15 cm from the syringe tips.
4. Incorporation of niacinamide: To prepare PLA-HA-NA mats, 0.01 g NA was dissolved in 5 mL of the 1 wt% HA solution, which was electrospun under the same optimized conditions.
5. Characterization and testing:
Mechanical properties: PLA-HA mats exhibited 4.93 MPa tensile strength, while PLA-HA-NA mats showed 4.1 MPa but greater elongation (91 ± 4.5 %).
Hydrophilicity: PLA-HA-NA mats displayed a 25° contact angle, indicating superior water absorption.
Drug release: 72.3 ± 3.6 % NA release occurred after 720 min, following the Korsmeyer-Peppas model (n = 0.29).
Biocompatibility: In vitro tests confirmed 94 % cell viability, while in vivo rat models achieved 96 ± 4.6 % wound closure by day 14.
This stepwise methodology demonstrates that niacinamide-loaded PLA-HA nanofibers provide both structural functionality and effective therapeutic performance for wound healing.
Lee, Si-Yeon, Ginnae Ahn, and Soon-Do Yoon. International Journal of Biological Macromolecules 232 (2023): 123382.
Niacinamide (NA), a well-known bioactive compound for skin-lightening and anti-inflammatory applications, was incorporated into mungbean starch (MS)-based biomaterials to develop a transdermal drug delivery system (TDDS) for hyperpigmentation therapy. The experimental process was as follows:
1. Preparation of base matrix: Polyvinyl alcohol (PVA) was dissolved in hot distilled water (95 °C). MS and plasticizers-glycerol (GL) or citric acid (CA)-were dispersed in water and stirred at 400 rpm for 30 min. Both solutions were maintained at 95 °C for 20 min.
2. Formation of gel solution: The two solutions were blended at 500 rpm for 60 min at room temperature to form a homogeneous gel. NA (0.5 g) was dissolved in 20 mL water and added dropwise for uniform distribution.
3. Casting and drying: The gel was poured into a pre-heated Teflon mold (200 × 200 × 1 mm), then dried in a ventilated oven at 50 °C for 20 h.
4. Crosslinking process: The dried biomaterials were irradiated with UV light (300 W) for 30 min, then conditioned at 25 °C and 55-60 % RH for one week.
Characterization (FE-SEM, FT-IR, ¹H NMR) confirmed material integrity. NA release reached 99 % within 10 min under acidic and high-temperature conditions, while sustained release was observed across artificial skin for 90 min. Functionally, CA-containing biomaterials achieved 55.8 % tyrosinase inhibition, 73.0 % antioxidant activity, and suppression of melanin synthesis in B16F10 cells.
These results highlight NA-imprinted starch-based biomaterials as effective carriers for skin depigmentation therapy.
Handayani, N. C., Risandiansyah, R., Safitri, A., Purnomo, Y., & Prananto, Y. P. (2023). Kuwait Journal of Science, 50(2), 47-52.
Niacinamide (NA), a versatile form of vitamin B3, has recently been explored in coordination chemistry to enhance its biomedical applications. In this study, Cu(II)-niacinamide complexes were synthesized using a layered solution method, employing various copper(II) salts (sulfate, nitrate, chloride, and acetate) with different metal-to-ligand ratios (1:2, 1:4, and 1:6).
1. Synthesis process: A water-methanol layer technique was used, with the bottom aqueous layer containing Cu(II) salt and the top methanolic layer containing niacinamide. A buffer layer (water-methanol, 1:1) facilitated gradual crystallization. Crystal growth initiated at the interface and matured over 21 days, after which the products were filtered, washed, and dried.
2. Characterization: Structural elucidation by IR spectroscopy, powder XRD, melting point determination, SEM, and qualitative anion tests confirmed distinct crystalline morphologies. Sulfate yielded light blue hair-like crystals, acetate produced dark green block crystals, and chloride generated turquoise sword-like microcrystals. Coordination varied, with sulfate and acetate acting as ligands, while chloride remained as a free anion in the lattice.
3. Proposed structures: Products were identified as [Cu(L)x(SO4)], [Cu(L)x]Cl2, and [Cu2(L)4(CH3COO)2], where L = niacinamide.
4. Biological evaluation: Antibacterial assays against E. coli and S. aureus demonstrated superior activity of all Cu(II)-niacinamide complexes compared with free niacinamide, suggesting synergistic antimicrobial enhancement via metal coordination.
This work illustrates the potential of niacinamide in metal-organic complexation, paving the way for multifunctional antibacterial agents.
What is the molecular formula of Niacinamide?
The molecular formula of Niacinamide is C6H6N2O.
What is the CAS number of Niacinamide?
The CAS number of Niacinamide is 98-92-0.
What are some synonyms for Niacinamide?
Some synonyms for Niacinamide are 3-Pyridinecarboxamide.
What is the IUPAC name of Niacinamide?
The IUPAC name of Niacinamide is Pyridine-3-carboxamide.
What is the density of Niacinamide?
The density of Niacinamide is 1.40g/ml.
What are the typical applications of Niacinamide?
The typical applications of Niacinamide include use as a dispersing agent, emulsion stabilizer, and as a micronutrient.
What is the boiling point of Niacinamide?
The boiling point of Niacinamide is 150-160 °C.
What is the melting point of Niacinamide?
The melting point of Niacinamide is 128-131 °C.
What is the percentage of actives present in Niacinamide?
Niacinamide contains 95% actives.
What is the pH range of Niacinamide when dissolved in water at 20°C?
The pH of Niacinamide is 6.0-7.5 when dissolved in water at 20°C.
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