dos Santos Silva, Lucas, et al. International Journal of Biological Macromolecules 271 (2024): 132577.
Staphylococcus aureus is a pathogen widely involved in wound infections because it can release various virulence factors that damage the skin healing process and has resistance mechanisms. In this study, sodium alginate and chitosan are combined to create a hydrogel for the local delivery of neomycin, aimed at combating Staphylococcus aureus associated with skin complications. The addition of neomycin imparts antimicrobial properties to the hydrogel.
Hydrogel Formulation: Sodium alginate is dissolved in distilled water at room temperature and stirred for 1 hour under constant magnetic stirring. Chitosan is dissolved in 0.2 mol/L acetic acid at room temperature and stirred for 24 hours under constant magnetic stirring. The polymer solutions of sodium alginate (50 mg/mL, distilled water) and chitosan (50 mg/mL, 0.2 mol/L acetic acid) are mixed in a container (9 times the volume of alginate: 1 volume of chitosan). Briefly, chitosan solution (10 mL) is dripped into the sodium alginate solution (45 mL). The mixture is continuously stirred, and the remaining sodium alginate solution (45 mL) is added until a uniform hydrogel is formed. Neomycin is diluted in saline solution (0.9% NaCl) and directly added to the hydrogel until the concentration reaches 0.4 mg of neomycin per mL of hydrogel. The product is stirred thoroughly for complete mixing.
Abdelhaq, Fatma El Zahraa M., et al. Inorganic Chemistry Communications 170 (2024): 113161.
The formulation of a drug plays an important role in its performance and efficacy. This work aims to compare the effectiveness of neomycin sulfate and the performance of ZnO-loaded hydrogels. Neomycin is added to enhance the synergistic antimicrobial activity.
Preparation of the Hydrogel: A typical procedure includes dispersing 1 gram of sodium alginate (SA) in distilled water and adding 0.1 gram of potassium persulfate (PPS) as an initiator. The mixture is placed in a water bath at a specific temperature and stirred for 20 minutes. Then, 1.5 grams of acrylamide (Am) and different concentrations of N,N'-methylenebisacrylamide (MBAm) (0.1%, 0.15%, 0.2% w/w) are added, and the resulting mixtures are labeled H1, H2, and H3, respectively. The mixture is vigorously stirred for a specific time. The prepared hydrogels are rinsed with an appropriate amount of ethanol to remove excess water. Afterward, the hydrogels are dried overnight at 45 °C for future use.
What is the CAS number for Neomycin B?
The CAS number for Neomycin B is 119-04-0.
What are the synonyms for Neomycin B?
The synonyms for Neomycin B are Framycetin and Soframycin.
What is the molecular weight of Neomycin B?
The molecular weight of Neomycin B is 614.64.
What is the molecular formula of Neomycin B?
The molecular formula of Neomycin B is C23H46N6O13.
What is the physical state of Neomycin B?
The physical state of Neomycin B is solid.
What are the typical applications of Neomycin B?
Neomycin B is used as an antimicrobial agent and an antibacterial agent.
Is Neomycin B a liquid or a solid?
Neomycin B is a solid.
What percentage of actives does Neomycin B contain?
Neomycin B contains 95% actives.
What is the chemical structure of Neomycin B?
The chemical structure of Neomycin B is D-Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-.
What are the potential uses of Neomycin B in medicine?
Neomycin B may be used as an antibiotic medication to treat bacterial infections.
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