Zhao, Kai-Hua, et al. Molecules 21.10 (2016): 1294.
Methyl glucoside (MG) plays a crucial role in the enzymatic synthesis of sugar fatty acid esters (SFAEs), which are widely used as biodegradable and biocompatible surfactants in the food, cosmetic, and pharmaceutical industries. This study highlights the esterification of MG with fatty acids catalyzed by Novozym 435, an immobilized lipase, under optimized reaction conditions.
The reaction was carried out in a 5-mL sealed test tube containing MG (0.058 g, 0.3 mol/L), a fatty acid (0.3 M), and molecular sieves (150 mg) in a solvent system consisting of 2M2B, ionic liquids (ILs), or IL/2M2B mixtures. Novozym 435 (10 mg) was introduced, and the system was maintained at 45°C with continuous agitation at 300 rpm. The esterification process was monitored using high-performance liquid chromatography (HPLC), with conversion efficiency determined as the molar ratio of the ester formed relative to the initial MG content.
This enzymatic strategy offers a green and efficient alternative to chemical synthesis, demonstrating high substrate specificity and operational stability. The use of ILs and deep eutectic solvents (DESs) as reaction media further enhances reaction efficiency, providing tunable environments for selective esterification. Given the increasing demand for eco-friendly surfactants, MG-based SFAEs present a promising avenue for sustainable industrial applications, aligning with green chemistry principles.
Yuan, Hua, et al. Chemical Engineering Journal 207 (2012): 72-75.
Methyl glucoside (MGP) serves as an essential precursor in the selective catalytic oxidation process for synthesizing glucuronic acid and glucuronolactone. This transformation is efficiently catalyzed by Pd/CuO-Ce₀.₅Mn₀.₅O₂, which facilitates the oxidation under controlled reaction conditions.
The oxidation process begins with dissolving 6.0 g of MGP in 50 mL of water, followed by the addition of 1.0 g of the catalyst. Continuous stirring and bubbling ensure uniform dispersion, while the pH is maintained at 8-10 by the dropwise addition of 1 M NaOH. The reaction is conducted at 70°C for 5 hours, enabling selective oxidation of MGP into intermediate glucuronate derivatives. Post-reaction, the filtrate undergoes acidification with HCl to a low pH (1-2), followed by hydrolysis at 90°C for 3 hours, leading to the formation of glucuronic acid and glucuronolactone.
This catalytic approach presents an efficient and environmentally friendly method for converting MGP into valuable bioactive compounds used in pharmaceutical and biochemical applications. The use of Pd/CuO-Ce₀.₅Mn₀.₅O₂ enhances reaction selectivity and efficiency, making this process a promising pathway for industrial-scale production of glucuronic acid derivatives.
What is the product name of CAS number 3149-68-6?
The product name is Methyl glucoside.
What are the synonyms for Methyl glucoside?
The synonyms are D-Glucopyranoside, methyl and 1-O-Methyl-D-glucopyranose.
What is the molecular weight of Methyl glucoside?
The molecular weight of Methyl glucoside is 194.18.
What is the molecular formula of Methyl glucoside?
The molecular formula of Methyl glucoside is C7H14O6.
What is the percentage of actives in Methyl glucoside?
The percentage of actives in Methyl glucoside is 95%.
What is the physical state of Methyl glucoside?
The physical state of Methyl glucoside is solid.
What are the typical applications of Methyl glucoside?
The typical applications of Methyl glucoside are as an emulsifying agent and dispersing agent. It is also used as an intermediate in organic synthesis.
How is Methyl glucoside used as an emulsifying agent?
Methyl glucoside can help stabilize oil-in-water or water-in-oil emulsions by reducing the surface tension between the two phases.
How can Methyl glucoside be used as a dispersing agent?
Methyl glucoside can aid in dispersing solid particles in a liquid medium, helping to prevent clumping or settling.
What is the significance of Methyl glucoside as an intermediate in organic synthesis?
Methyl glucoside can be chemically modified to create a variety of compounds with different properties, making it a versatile building block in organic synthesis processes.
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