Abou-Elnour, Fatma S., et al. International Journal of Pharmaceutics 656 (2024): 124086.
Methyl dihydrojasmonate (MJ) was incorporated into nanostructured lipid carriers (NLCs) using a melt emulsification and ultrasonication technique to enhance drug delivery efficiency. The preparation process began with melting Compritol® 888 ATO and MJ at 85°C under continuous stirring. Simultaneously, an aqueous phase containing poloxamer 407 (P407) in deionized water was heated to the same temperature. The molten lipid phase was then emulsified with the aqueous phase by stirring at 500 rpm.
To achieve nanoscale particle formation, the emulsion was ultrasonicated at 60% amplitude using a probe-type ultrasonic homogenizer for varying durations (5-10 minutes). After ultrasonication, the dispersion was rapidly cooled in an ice bath (2-3°C) for 5 minutes to induce particle solidification. Different formulation parameters, including lipid-to-oil ratios (1:1, 1.5:1, or 3:1 w/w), total lipid concentrations (2-4% w/v), and P407 concentrations (1-2% w/v), were systematically optimized to obtain stable dispersions.
For solid-state characterization, MJ-NLC dispersions were frozen at -80°C for 24 hours and lyophilized under vacuum (0.4 bar) for 24 hours. The optimized MJ-NLCs were further used as a lipid matrix for ivermectin co-loading, demonstrating their potential as an advanced nanocarrier system. This study underscores the precise formulation strategies required to develop stable and effective lipid-based drug delivery platforms.
What is the product name of CAS number 37172-53-5?
The product name is Methyl dihydrojasmonate.
What are the synonyms for Methyl dihydrojasmonate?
The synonyms are Cyclopentanecarboxylic acid, 2-hexyl-3-oxo-, methyl ester; Methyl 2-hexyl-3-oxocyclopentanecarboxylate; Methyl hexyl cyclopentanone carboxylate; FEMA No. 3408.
What is the molecular weight of Methyl dihydrojasmonate?
The molecular weight is 226.31.
What is the molecular formula of Methyl dihydrojasmonate?
The molecular formula is C13H22O3.
What is the percentage of actives in Methyl dihydrojasmonate?
The percentage of actives is 95%.
What is the physical state of Methyl dihydrojasmonate?
The physical state is a liquid.
What are the typical applications of Methyl dihydrojasmonate?
It is used as a perfume.
Is Methyl dihydrojasmonate a natural or synthetic compound?
It is a synthetic compound.
Can Methyl dihydrojasmonate be used in food products?
Yes, it can be used in food as it has FEMA No. 3408 designation.
What is the chemical structure of Methyl dihydrojasmonate?
The chemical structure has a cyclopentane ring with a hexyl side chain and a ketone functional group.
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