Magnesium ascorbyl phosphate

Catalog Number

ACM113170551-1

CAS

113170-55-1

Structure

Synonyms

Ascorbic acid, monoester with phosphoric acid, magnesium salt (2:3)

Molecular Weight

579.08

Molecular Formula

C12H12Mg3O18P2

Active Content

90%

Physical State

Solid

Typical Applications

Use as antioxidant.

MSDS

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COA

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Spec Sheet

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Case Study

Magnesium Ascorbyl Phosphate for Enzymatically Induced Remediation and Reinforcement of Cr(VI)-Contaminated Soil

Magnesium Ascorbyl Phosphate for Enzymatically Induced Remediation and Reinforcement of Cr(VI)-Contaminated Soil Han, Lijun, et al. Journal of Hazardous Materials 448 (2023): 130860.

This study presents a novel remediation approach utilizing magnesium ascorbyl phosphate (MAP) in combination with phytase to simultaneously detoxify hexavalent chromium \[Cr(VI)] and improve the mechanical strength of contaminated soil. In the process, phytase catalyzes MAP hydrolysis, releasing ascorbic acid (AA) and generating MgHPO₄·3H₂O precipitates. The liberated AA effectively reduces highly toxic Cr(VI) to low-toxicity Cr(III), which subsequently precipitates as Cr(OH)₃ and CrPO₄, immobilizing the contaminant.
Experimental trials demonstrated that at the geotechnically optimal soil moisture content (16.8 %), 5 % MAP (wt% of soil) with 1 % phytase (v/v of soil water) achieved over 90 % reduction of 500 mg/kg Cr(VI). Lower contamination levels (≤100 mg/kg) showed up to 99.9 % Cr(VI) removal at 1 % MAP dosage, whereas highly contaminated soils required higher MAP doses to achieve comparable performance.
In addition to chemical stabilization, the process significantly enhanced geotechnical properties. The in-situ precipitation of MgHPO₄·3H₂O within soil pores acted as a cementing agent, increasing unconfined compressive strength by more than two-fold compared to untreated Cr(VI)-contaminated soil.
This dual-function MAP-phytase treatment offers an eco-friendly and practical solution for contaminated site rehabilitation, integrating heavy metal detoxification with structural reinforcement. Its potential for large-scale application warrants further studies on long-term stability, environmental compatibility, and field-scale demonstration.

Magnesium Ascorbyl Phosphate for Multifunctional Hydrogel Scaffolds in Cranial Bone Defect Repair

Magnesium Ascorbyl Phosphate for Multifunctional Hydrogel Scaffolds in Cranial Bone Defect Repair Zhang, Zhen, et al. Chemical Engineering Journal 472 (2023): 145061.

This study introduces magnesium ascorbyl phosphate (MAP) as a multifunctional small-molecule therapeutic for in situ cranial defect repair, integrating antioxidant, osteogenic, and angiogenic functions. MAP was incorporated into a gelatin methacrylate (GelMA) hydrogel to enable sustained release, providing phosphorus-based compounds without the need for exogenous Ca²⁺ supplementation.
in vitro, MAP-loaded hydrogels exhibited excellent biocompatibility and mechanical stability. MAP reduced oxidative stress in bone marrow-derived mesenchymal stem cells (BMSCs) by scavenging reactive oxygen species, while enhancing Ca²⁺ uptake and accelerating biomineralization. Importantly, mitochondrial function remained intact. The material also activated the ERK/AKT signaling pathways, promoting BMSC proliferation, migration, and osteogenic differentiation.
in vivo, implantation of the MAP hydrogel scaffold in rat cranial defects significantly enhanced angiogenesis and bone regeneration. Micro-CT analysis at 8 weeks revealed a defect repair rate of 32.74 ± 0.62 % in the MAP group, compared to 7.08 ± 0.29 % in controls. This repair was achieved without external calcium sources, reflecting the "phosphorus-capturing calcium" concept in which endogenous calcium is mobilized to form new bone mineral.
The findings highlight MAP's potential as a multifunctional bioactive for bone tissue engineering. By combining antioxidant protection, osteoinduction, and vascularization within a single calcium-free hydrogel platform, MAP offers a promising strategy for advanced, cell-free bone defect repair systems.

Magnesium Ascorbyl Phosphate for Collagen Stabilization in Advanced Wound Healing Applications

Magnesium Ascorbyl Phosphate for Collagen Stabilization in Advanced Wound Healing Applications Lakra, Rachita, Manikantan Syamala Kiran, and Purna Sai Korrapati. International Journal of Biological Macromolecules 166 (2021): 333-341.

This study explores the role of magnesium ascorbyl phosphate (MAP) in enhancing the physico-chemical properties of collagen for wound healing applications. Collagen, a key extracellular matrix component, provides structural support for tissue repair but suffers from poor mechanical stability. MAP was incorporated during collagen fibril formation at final concentrations of 250-1000 μM, yielding reconstituted collagen films with superior stability and mechanical performance.
MAP accelerated collagen fibrillation, indicating enhanced molecular interactions without altering the protein's secondary structure. Rheological analysis demonstrated increased shear viscosity across varying shear rates, confirming improved viscoelastic properties. Differential scanning calorimetry revealed elevated denaturation temperatures in MAP-stabilized films, while tensile testing showed higher Young's modulus compared to native collagen films, reflecting improved stiffness and resilience.
in vivo wound healing studies in rats demonstrated complete wound closure by day 16 with MAP-collagen film treatment. Mechanical testing of the regenerated skin showed full recovery of tensile properties, closely matching those of normal skin. The results indicate that MAP's stabilization effect preserves collagen's biological compatibility while enhancing its thermal and mechanical durability.
By integrating MAP into collagen matrices, this approach offers a promising biomaterial platform for wound dressings that combine structural integrity, biocompatibility, and accelerated healing. MAP thus serves not only as an antioxidant but also as a molecular stabilizer, enabling the design of high-performance collagen-based scaffolds for regenerative medicine.

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