Bai, Rongxian, et al. Tetrahedron 72.17 (2016): 2170-2177.
A three-component reaction of 4-hydroxyindole, an aldehyde, and malonitrile or ethyl cyanoacetate has been developed using potassium fluoride (KF) or diethylamine as catalysts, which readily yields 3,4-fused tricyclic indoles with good to excellent yields.
Experimental Procedure: The reaction was conducted in a 20 mL V-shaped tube with a triangular magnetic stirring bar. In a typical reaction, 4-hydroxyindole (0.4 mmol) was mixed with malonitrile (0.4 mmol) and an aldehyde (0.4 mmol) in 2.0 mL of ethanol. Potassium fluoride (0.08 mmol) was then added. The mixture was heated to 60 °C under stirring and maintained for 6 hours. After the reaction was complete, the mixture was cooled to room temperature, and the target product was isolated using preparative thin-layer chromatography (TLC), with a mobile phase of petroleum ether/ethyl acetate = 3/1 (v/v) for elution.
What is the product name of CAS number 2380-94-1?
The product name is 4-Hydroxyindole.
What is the synonym for 4-Hydroxyindole?
The synonym is 1H-Indol-4-ol.
What is the molecular weight of 4-Hydroxyindole?
The molecular weight is 133.15.
What is the melting point of 4-Hydroxyindole?
The melting point is 97-99 °C- lit.
What is the purity of 4-Hydroxyindole?
The purity is 98.0%+.
What is the appearance of 4-Hydroxyindole?
The appearance is grey crystalline.
What are the actives of 4-Hydroxyindole?
The actives are 95%.
What is the physical state of 4-Hydroxyindole?
The physical state is solid.
What are the typical applications of 4-Hydroxyindole?
It is used as an antioxidant.
What is the molecular formula of 4-Hydroxyindole?
The molecular formula is C8H7NO.
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