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Glyceryl dibehenate

Catalog Number

ACM99880645-2

CAS

99880-64-5

Structure

IUPAC Name

Docosanoic acid;propane-1,2,3-triol

Synonyms

Docosanoic acid, diester with 1,2,3-propanetriol

Molecular Weight

737.23

Molecular Formula

C47H92O5

Canonical SMILES

CCCCCCCCCCCCCCCCCCCCCC(=O)O.C(C(CO)O)O

InChI

BYNVYIUJKRRNNC-UHFFFAOYSA-N

InChI Key

InChI=1S/C22H44O2.C3H8O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24;4-1-3(6)2-5/h2-21H2,1H3,(H,23,24);3-6H,1-2H2

Melting Point

50-52 °C

Active Content

95%

Physical State

Solid

Typical Applications

Use as lubricant.
Use as dispersing agent, emulsion stabilizer.

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

Case Study

Glyceryl Dibehenate Used for the Preparation of Lyotropic Liquid Crystal Nanoparticles

Glyceryl Dibehenate Used for the Preparation of Lyotropic Liquid Crystal Nanoparticles Atlıbatur, Rüya, et al. Journal of Drug Delivery Science and Technology 87 (2023): 104821.

In this study, glyceryl dibehenate (GDB) was employed as a key lipid component in combination with glyceryl monostearate (GMS) to formulate lyotropic liquid crystal nanoparticles (LLCNs) for drug delivery applications. GDB played a vital role in modulating the lipid phase behavior, facilitating the formation of mesophase structures with favorable loading and pharmacokinetic properties.
The LLCNs were synthesized using a film preparation-rehydration technique. Specifically, a 70 mg lipid mixture containing equal parts GDB and GMS was dissolved in ethanol. Solvent removal was achieved through rotary evaporation at 60 °C and 150 rpm under vacuum, followed by an additional 2-hour evaporation step to eliminate residual solvent. A thin lipid film formed on the flask wall was rehydrated using 10 mL of Pluronic F-127 surfactant solution prepared in distilled water.
The mixture was then subjected to ultrasonic agitation at 50 °C for 5 minutes and vortexed for 2 minutes to facilitate dispersion. This cycle was repeated twice to ensure complete hydration and particle stabilization. Selected formulations were further loaded with curcumin by co-dissolving it in the ethanol phase before film formation.
This approach marks the first reported use of glyceryl dibehenate in combination with GMS to generate LLCNs via film hydration, offering a novel platform for lipid-based drug delivery systems with enhanced versatility and structural control.

Glyceryl Dibehenate Used for the Preparation of Nanostructured Lipid Carriers via Ultrasonication and High-Pressure Homogenization

Glyceryl Dibehenate Used for the Preparation of Nanostructured Lipid Carriers via Ultrasonication and High-Pressure Homogenization Krambeck, K., et al. Colloids and Surfaces B: Biointerfaces 193 (2020): 111057.

Glyceryl dibehenate, a high-melting-point lipid (65-77 °C), was employed as a key solid lipid in the formulation of nanostructured lipid carriers (NLCs) designed for enhanced topical delivery of antioxidant-rich passion fruit seed oil. This study aimed to compare two preparation techniques-ultrasonication (UL) and high-pressure homogenization (HPH)-for fabricating NLCs using glyceryl dibehenate, glyceryl distearate, and cetyl palmitate as solid lipids.
For both methods, glyceryl dibehenate and passion fruit seed oil were first melted at 10 °C above the lipid's melting point. An aqueous phase, preheated to the same temperature, was then added under vigorous agitation using an Ultra-Turrax at 8500 rpm for 5 minutes, yielding a coarse pre-emulsion.
In the UL method, this pre-emulsion was further sonicated with a 6 mm probe at 70% amplitude for 15 minutes, followed by rapid cooling in an ice bath for 30 minutes to solidify the NLCs. For the HPH method, the pre-emulsion underwent two homogenization cycles at 500 bar and 70 ± 0.5 °C using a high-pressure homogenizer.
The use of glyceryl dibehenate contributed to the thermal stability and structural integrity of the NLC matrix, supporting its suitability for encapsulating bioactives in dermatological applications. All formulations were prepared in triplicate, ensuring reproducibility.

Custom Q&A

What is the CAS number of Glyceryl dibehenate?

The CAS number of Glyceryl dibehenate is 99880-64-5.

What are the synonyms for Glyceryl dibehenate?

The synonyms for Glyceryl dibehenate are Docosanoic acid, diester with 1,2,3-propanetriol.

What is the IUPAC name of Glyceryl dibehenate?

The IUPAC name of Glyceryl dibehenate is Docosanoic acid;propane-1,2,3-triol.

What is the molecular weight of Glyceryl dibehenate?

The molecular weight of Glyceryl dibehenate is 737.23.

What is the molecular formula of Glyceryl dibehenate?

The molecular formula of Glyceryl dibehenate is C47H92O5.

What is the SMILES representation of Glyceryl dibehenate?

The SMILES representation of Glyceryl dibehenate is CCCCCCCCCCCCCCCCCCCCCC(=O)O.C(C(CO)O)O.

What is the InChl Key of Glyceryl dibehenate?

The InChI Key of Glyceryl dibehenate is InChI=1S/C22H44O2.C3H8O3.

What is the melting point of Glyceryl dibehenate?

The melting point of Glyceryl dibehenate is 50-52 °C.

What is the percentage of actives in Glyceryl dibehenate?

The percentage of actives in Glyceryl dibehenate is 95%.

What are the typical applications of Glyceryl dibehenate?

The typical applications of Glyceryl dibehenate are use as a lubricant, use as a dispersing agent, and emulsion stabilizer.

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