Li, Junbiao, et al. Materials Letters 379 (2025): 137644.
Glucosylrutin (GR) has been successfully incorporated into sunscreen multiple emulsions to enhance UV protection and antioxidant activity. In this study, a "two films and three phases" structure was developed using a two-step emulsification method, where GR was dissolved in the inner aqueous phase, while the oil phase contained the triazine-based UV absorber BEMT. This formulation effectively combines the UV-absorbing properties of GR and BEMT to cover a broader UV spectrum, providing synergistic protection.
The preparation involved first creating a water-in-oil (W/O) emulsion by mixing 1 wt% GR with a solution of BEMT in white oil, followed by the addition of an aqueous solution containing Tween80 to form a water-in-oil-in-water (W/O/W) emulsion. The final emulsion demonstrated optimized morphology, stability, and enhanced rheological properties. UV absorption spectra showed that BEMT primarily absorbs UV in the 290-360 nm range, while GR absorbs between 340-380 nm, confirming their complementary UV defense mechanism.
The study highlights the potential of GR to enhance sunscreen formulations, leveraging both UV protection and antioxidant properties, making it a promising ingredient for improved sun protection products. The morphological stability and physical properties of the emulsion also support its application in cosmetic and pharmaceutical formulations.
Seto, Hirokazu, et al. Advanced Powder Technology 31.9 (2020): 4129-4133.
Glucosylrutin (G-rutin) has been effectively utilized to coat gold nanoparticles (AuNPs) for the selective detection of proteins. In this study, G-rutin was adsorbed onto 40 nm gold nanoparticles, maintaining their colloidal stability and preventing aggregation or color change. The G-rutin-coated gold nanoparticles demonstrated selective binding affinity for concanavalin A, a protein that specifically interacts with glucosides and mannosides. Upon the addition of concanavalin A, a color change from red to reddish-violet occurred, indicating a successful protein detection. The extent of the color change was directly proportional to the concentration of concanavalin A, while other proteins, such as bovine serum albumin and peanut agglutinin, did not elicit any color change, demonstrating the specificity of the assay.
The preparation of G-rutin-coated gold nanoparticles was achieved through a simple one-step coating process. G-rutin was dissolved in phosphate buffer and mixed with gold nanoparticle dispersions, followed by 48 hours of stirring in the dark. Characterization techniques, including dynamic light scattering (DLS) and X-ray photoelectron spectroscopy (XPS), confirmed the successful coating of G-rutin on the gold surface. The size of the G-rutin-coated gold nanoparticles increased from 39.7 ± 0.3 nm to 44.3 ± 1.4 nm, while their dispersion remained stable, showcasing the potential of G-rutin in biosensing applications.
Kadota, Kazunori, et al. Powder Technology 323 (2018): 69-75.
α-Glucosyl rutin (rutin-G) has been investigated as an effective grinding aid for wet bead milling of itraconazole (ITCZ), a poorly water-soluble drug. The study demonstrated that rutin-G significantly improved the dissolution rate of ITCZ compared to other grinding aids. However, excessive milling with rutin-G led to a decrease in the dissolution rate, indicating the importance of milling time in optimizing drug formulation.
The preparation of ITCZ formulations involved wet bead milling, where ITCZ was ground with rutin-G, and the dissolution profiles were measured. Structural analysis using powder X-ray diffraction (PXRD) and small-angle X-ray scattering (SAXS) revealed changes in the molecular and composite structures of ITCZ as milling time progressed. For milling times up to 5 hours, the molecular-level structure remained stable, but a 10-hour milling period induced significant structural changes, resulting in the formation of new composite structures between ITCZ and rutin-G.
The study suggests that rutin-G enhances the solubility of ITCZ by affecting particle size and structure during milling, but excessive milling can lead to detrimental structural changes. This research highlights the potential of rutin-G as a functional excipient in pharmaceutical formulations, specifically for poorly water-soluble drugs like ITCZ, by improving dissolution profiles under controlled milling conditions.
What is the chemical formula of Glucosylrutin?
The chemical formula of Glucosylrutin is C33H40O21.
What is the CAS number of Glucosylrutin?
The CAS number of Glucosylrutin is 130603-71-3.
What is the molecular weight of Glucosylrutin?
The molecular weight of Glucosylrutin is 772.66.
What is the physical state of Glucosylrutin?
Glucosylrutin is in a solid physical state.
What are some of the synonyms for Glucosylrutin?
Some synonyms for Glucosylrutin include 4(G)-alpha-Glucopyranosyl-rutin, and 4H-1-Benzopyran-4-one.
What are the typical applications of Glucosylrutin?
Glucosylrutin is typically used as an antioxidant.
What percentage of Glucosylrutin is considered active?
Glucosylrutin is considered to be 95% active.
What are the components of the chemical structure of Glucosylrutin?
The chemical structure of Glucosylrutin includes 3-((O-6-deoxy-alpha-L-mannopyranosyl-(1-6)-O-(alpha-D-glucopyranosyl-(1-4))-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy.
What are some potential benefits of using Glucosylrutin as an antioxidant?
Glucosylrutin can help protect cells from damage caused by free radicals and oxidative stress.
How can Glucosylrutin be utilized in practical applications?
Glucosylrutin can be used in various products such as skincare formulations, dietary supplements, and pharmaceuticals for its antioxidant properties.
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