Ma, Shuai, et al. Journal of Colloid and Interface Science 677 (2025): 632-644.
Glucosamine Sulfate (GAS) is a widely used bioactive molecule in cartilage tissue regeneration due to its potential to stimulate cartilage repair. This study demonstrates the incorporation of GAS into a novel, cell- and growth factor-free nanofibrous sponge designed for cartilage defect repair. The sponge, made from carboxymethyl chitosan (CMC) as the framework and silk fibroin (SF)-Polycaprolactone (PCL) nanofibers as an internal support, encapsulates GAS within a core-shell structure. This structure serves as both a mechanical scaffold and a long-lasting drug delivery system, ensuring continuous release of GAS for up to 30 days.
The core-shell nanofibers enhance the mechanical properties of the scaffold, closely mimicking the extracellular matrix of cartilage, while promoting cell adhesion and nutrient transport. The controlled release of GAS accelerates cartilage tissue repair in a rat cartilage defect model, highlighting its effectiveness in tissue regeneration. Moreover, the sponge's structure remains highly elastic even after multiple compression cycles, making it ideal for dynamic cartilage environments.
This approach represents an innovative method for localized drug delivery, minimizing systemic effects and ensuring the sustained efficacy of GAS, making it a promising strategy for cartilage tissue engineering and regeneration.
Chen, Wei, et al. Carbohydrate Polymers 229 (2020): 115544.
Glucosamine Sulfate (GAS), derived from chitin, plays a critical role in chondrocyte growth and cartilage regeneration. In this study, GAS was successfully encapsulated into polycaprolactone (PCL) nanofibers using coaxial electrospinning technology. This method protects GAS from environmental degradation and ensures its sustained release, a key factor in long-term therapeutic applications for cartilage repair.
The electrospun PCL/GAS composite mats, prepared with different GAS concentrations (5% and 10%), displayed a typical nanofiber scaffold structure, confirmed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Energy dispersive X-ray spectroscopy (EDX) further verified the incorporation of GAS within the PCL fibers. Tensile testing showed that the PCL/GAS mats exhibited excellent mechanical properties, capable of stretching over twice their original length.
Cellular assays demonstrated that the PCL/GAS composite mats significantly promoted the proliferation and growth of rat articular chondrocytes, highlighting their potential in cartilage tissue engineering. The in vitro release profile of GAS, monitored in simulated body fluid (SBF) under controlled conditions, showed a gradual and sustained release, supporting its application for cartilage regeneration.
This study demonstrates the promising application of GAS-loaded PCL nanofibers as a drug delivery system for cartilage regeneration, offering both mechanical stability and effective sustained release for therapeutic use.
What is the CAS number for Glucosamine sulfate?
The CAS number for Glucosamine sulfate is 29031-19-4.
What are some synonyms for Glucosamine sulfate?
Some synonyms for Glucosamine sulfate include D-Glucose, 2-amino-2-deoxy-, and sulfate (salt).
What is the active ingredient percentage in Glucosamine sulfate?
The active ingredient percentage in Glucosamine sulfate is 95%.
In what physical state is Glucosamine sulfate typically found?
Glucosamine sulfate is typically found in a solid physical state.
What are some typical applications of Glucosamine sulfate?
Some typical applications of Glucosamine sulfate include use as an emulsifying agent, dispersing agent, and antistatic agent.
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