Mickymaray, Suresh, et al. International Journal of Biological Macromolecules 248 (2023): 125799.
Farnesol (FAR), a naturally occurring sesquiterpene, has demonstrated significant therapeutic potential in nanotechnology-driven biomedical applications. In recent research, Chitosan-encapsulated-NiO-TiO₂-Farnesol hybrid nanomaterials (CNTF HNMs) were synthesized to enhance their antibacterial and anticancer efficacy.
The fabrication process involved blending TiO₂ nanoparticles with Ni(NO₃)₂·6H₂O, followed by chitosan dissolution in acetic acid. Farnesol was incorporated into the mixture, and NaOH was added to induce nanoparticle formation. The resultant nanomaterials underwent calcination at 600 °C to achieve a final crystalline structure, with an average crystallite size of 34.8 nm.
CNTF HNMs exhibited potent antibacterial activity against ATCC reference strains (S. aureus, E. coli, P. aeruginosa) and multidrug-resistant pathogens. Additionally, cytotoxicity assays, including MTT and Annexin-V/PI, confirmed their effectiveness against MDA-MB-231 breast cancer cells. Mechanistic studies indicated that CNTF HNMs promoted reactive oxygen species (ROS) accumulation, disrupted mitochondrial membrane potential (Δψm), and induced intrinsic apoptotic pathways.
These findings suggest that farnesol-functionalized nanohybrids hold promise as dual-action antibacterial and anticancer agents, warranting further molecular studies for clinical translation.
Santos, Anamaria Mendonça, et al. Carbohydrate Research (2025): 109406.
Farnesol (FAR), a sesquiterpene alcohol with hydrophobic properties, faces solubility limitations that hinder its pharmaceutical applications. To overcome this challenge, inclusion complexes of FAR with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) were successfully prepared using a freeze-drying method.
A 1:1 molar ratio of FAR to β-CD and HP-β-CD was used, with β-CD solubilized at room temperature and HP-β-CD at 40 °C. Following the addition of FAR, the solution was stirred for 36 hours before being frozen at -40 °C and subjected to freeze-drying. The resulting inclusion complexes were stored in airtight conditions to maintain stability. For comparison, physical mixtures of FAR and cyclodextrins were prepared via manual mixing.
The encapsulation of FAR within cyclodextrin cavities enhances its solubility and stability, potentially improving its therapeutic index. These inclusion complexes provide a promising strategy for increasing the bioavailability of hydrophobic compounds like FAR, expanding its applications in pharmaceutical formulations.
Tang, N., Xing, X., Li, H., Wang, S., Ji, S., Yang, Y., & Ai, Z. (2025). Food Bioscience, 106412.
Farnesol (FAR), a fungal quorum-sensing molecule, plays a crucial role in microbial physiology by regulating morphological transitions and secondary metabolite production. Recent studies have demonstrated that FAR influences yeast-to-hypha differentiation and enhances squalene biosynthesis in Saccharomycopsis fibuligera.
To investigate these effects, S. fibuligera was cultured in YPD media containing varying concentrations of FAR (0-125 μmol/L) and incubated at 32 °C under shaking conditions. Morphological analysis revealed that increasing FAR concentrations suppressed hyphal formation while promoting yeast-like growth. Concurrently, metabolomic and proteomic analyses, supported by molecular docking simulations, identified the upregulation of squalene synthase (SfSQS) in response to FAR exposure. These findings suggest that FAR directly modulates squalene biosynthesis, a key precursor in sterol and terpenoid metabolism.
By simultaneously regulating fungal morphogenesis and lipid metabolism, FAR presents potential applications in industrial biotechnology for enhanced squalene production. Further molecular studies are required to elucidate the precise regulatory mechanisms governing this dual role.
What is the CAS number for Farnesol?
The CAS number for Farnesol is 4602-84-0.
What are some synonyms for Farnesol?
Some synonyms for Farnesol include (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol.
What is the molecular weight of Farnesol?
The molecular weight of Farnesol is 222.37.
What is the molecular formula of Farnesol?
The molecular formula of Farnesol is C15H26O.
What is the purity of Farnesol?
The purity of Farnesol is 99%.
What percentage of actives does Farnesol contain?
Farnesol contains 95% actives.
What is the physical state of Farnesol?
Farnesol is in the liquid state.
What are some typical applications of Farnesol?
Some typical applications of Farnesol include use as perfume, use as intermediate in organic synthesis, and use as insect attractant.
What are the possible uses of Farnesol in organic synthesis?
Farnesol can be used as an intermediate in organic synthesis.
What are the potential benefits of using Farnesol as an insect attractant?
Farnesol can be used as an insect attractant to lure insects for research or pest control purposes.
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