Duan, Yin, et al. "The cannabinoid receptor agonist CP-55,940 and ethyl arachidonate interfere with [3H] batrachotoxinin A 20 α-benzoate binding to sodium channels and inhibit sodium channel function." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 148.3 (2008): 244-249.
Ethyl arachidonate, an ester analog of anandamide, has been studied for its effects on voltage-gated sodium channels (VGSCs) in the brain. In this investigation, the cannabinoid-1 (CB1) receptor agonist CP-55,940 and ethyl arachidonate were tested for their ability to alter [3H]batrachotoxinin A 20 α-benzoate ([3H]BTX-B) binding and VGSC-dependent depolarization in mouse brain synaptoneurosomes. Ethyl arachidonate inhibited [3H]BTX-B binding at an IC50 of 262.7 µM, demonstrating its role as a partial inhibitor compared to CP-55,940, which had a much lower IC50 of 22.3 µM. Neither compound's effects on binding were influenced by the CB1 receptor antagonist AM251, indicating that these inhibitors operate independently of CB1 receptor activation.
Kinetic analyses showed that ethyl arachidonate, like CP-55,940, accelerated the dissociation of [3H]BTX-B from VGSCs, positioning it as an allosteric inhibitor. Notably, ethyl arachidonate also inhibited veratridine-induced depolarization, with a higher IC50 than CP-55,940. These findings suggest that ethyl arachidonate may contribute to the depressant effects of alcohol by interacting with both VGSCs and CB1 receptors in the brain. This research expands the understanding of how alcohol metabolites like ethyl arachidonate can influence ion channel function, potentially explaining some of alcohol's neuropharmacological effects.
Kashchenko, Nina I., Daniil N. Olennikov, and Nadezhda K. Chirikova. Applied Sciences 11.23 (2021): 11099.
Ethyl arachidonate (100 mg/L) has been identified as an effective elicitor to enhance the productivity of Silene repens seedlings in chemical studies focused on ecdysteroid and glycosylflavone accumulation. When applied via foliar spraying, ethyl arachidonate significantly increased the yield of S. repens leaves (from 60.0 to 113.3 mg) and roots (from 51.2 to 73.2 mg) compared to control groups. Despite this productivity boost, the concentration of key ecdysteroids-20-hydroxyecdysone and polypodine B-was lower than in untreated samples.
This observation suggests that while ethyl arachidonate promotes biomass production, it does not necessarily optimize the content of specific bioactive compounds. For higher ecdysteroid yields, the application of epibrassinolide (100 mg/L) is more effective. Nonetheless, ethyl arachidonate's role as a growth enhancer in S. repens seedlings indicates its potential in agricultural and pharmacological applications where increased biomass is desired, particularly in the context of producing plant-based compounds such as ecdysteroids and glycosylflavones. The study underscores the nuanced effects of phytohormones and elicitors in plant biotechnology, paving the way for tailored cultivation strategies.
What is the CAS number of Ethyl arachidonate?
The CAS number of Ethyl arachidonate is 1808-26-0.
What are some synonyms for Ethyl arachidonate?
Some synonyms for Ethyl arachidonate are 5,8,11,14-Eicosatetraenoic acid, (all Z)-, ethyl ester; Ethyl 5,8,11,14-eicosatetraenoate, (all Z)-; Arachidonic acid, ethyl ester.
What is the molecular weight of Ethyl arachidonate?
The molecular weight of Ethyl arachidonate is 332.52.
What is the molecular formula of Ethyl arachidonate?
The molecular formula of Ethyl arachidonate is C22H36O2.
What is the flash point of Ethyl arachidonate?
The flash point of Ethyl arachidonate is 100.7°C.
What is the density of Ethyl arachidonate?
The density of Ethyl arachidonate is 0.899 g/cm³.
What percentage of Ethyl arachidonate is composed of actives?
Ethyl arachidonate is composed of 95% actives.
What is the physical state of Ethyl arachidonate?
The physical state of Ethyl arachidonate is a liquid.
What are some typical applications of Ethyl arachidonate?
Some typical applications of Ethyl arachidonate are as a lubricant, dispersing agent, and emulsion stabilizer.
How is Ethyl arachidonate commonly used in industrial applications?
Ethyl arachidonate is commonly used as a lubricant and as a dispersing agent and emulsion stabilizer in industrial applications.
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