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Ellagic acid

Catalog Number

ACM476664-5

CAS

476-66-4

Structure

IUPAC Name

6,7,13,14-Tetrahydroxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione

Synonyms

Eleagicacid

Molecular Weight

302.19

Molecular Formula

C14H6O8

Canonical SMILES

C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O

InChI

InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H

InChI Key

AFSDNFLWKVMVRB-UHFFFAOYSA-N

Boiling Point

363.24 °C

Melting Point

≥350 °C

Flash Point

310.1 °C

Purity

98%

Density

1.667 g/cm³

Solubility

Slightly soluble in alcohol, water

Appearance

Solid

Application

Ellagic acid, a cream to light yellow crystalline solid, is derived from various plants like Mangifera indica and Eucalyptus citriodora, and is soluble in methanol, ethanol, DMSO, and other organic solvents. Naturally occurring in fruits such as raspberries, strawberries, cranberries, and pomegranates, ellagic acid serves several vital roles. As a phenolic compound and antioxidant, it is utilized in both medicine and cosmetics due to its diverse biological activities, which include hemostatic, antineoplastic, antimutagenic, antiproliferative, and antiviral properties. Additionally, it serves as a skin lightening agent and shows potential in inhibiting enzymes like DNA topoisomerases and glycogen phosphorylase. Its antitumor and geroprotective effects, along with its role as a glutathione S-transferase inhibitor and its involvement in blood coagulation processes, underline its considerable potential health benefits and functional versatility.

Storage

2-8 °C

Active Content

95%

Physical State

Solid

Typical Applications

Use as antioxidant.

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

Case Study

Ellagic Acid as a Selective Depressant in Molybdenite-Galena Flotation Separation

Ellagic Acid as a Selective Depressant in Molybdenite-Galena Flotation Separation Tang, Honghu, et al. Applied Surface Science 686 (2025): 162117.

Ellagic acid (EA), a biodegradable small molecule, has been identified as a highly effective depressant for the selective flotation separation of molybdenite and galena. Due to their similar surface chemical properties, conventional separation methods face challenges in achieving high selectivity. However, EA selectively modifies the surface chemistry of galena, significantly reducing its recovery while maintaining high molybdenite recovery.
Flotation experiments demonstrated that at an optimal pH of 9, adding only 2 mg/L EA drastically reduced galena recovery from 74.44% to 3.44%, whereas molybdenite recovery remained above 90%. Additionally, the presence of n-dodecane at 1.25 × 10⁻⁴ mol/L further improved molybdenite recovery to 90.10%, while keeping galena recovery at minimal levels (~10%). The dosage-dependent analysis confirmed that increasing EA concentration from 0 to 1 mg/L led to a significant decline in galena recovery while molybdenite recovery remained unaffected.
These results highlight EA's strong depression effect on galena and its potential as an environmentally friendly alternative to conventional depressants in flotation processes. The low effective dosage (1-2 mg/L) further enhances its industrial applicability for efficient molybdenite-galena separation, promoting sustainable mineral processing solutions.

Ellagic Acid-Modified Chitosan Films for Enhanced Mechanical Performance

Ellagic Acid-Modified Chitosan Films for Enhanced Mechanical Performance Zasada, L., et al. Polymer Degradation and Stability 234 (2025): 111200.

Ellagic acid (EA), a natural polyphenol with antioxidant and antimicrobial properties, has been incorporated into chitosan (CTS)-based films to enhance their mechanical characteristics. In a recent study, CTS films were modified with varying concentrations of EA (0.2% and 0.4% by weight), resulting in improved structural integrity compared to unmodified CTS films.
The synthesis involved dissolving chitosan in 0.1 M acetic acid and EA in 0.0015 M NaOH, followed by blending at specific weight ratios (99.8CTS/0.2EA and 99.6CTS/0.4EA). The solutions were stirred and cast into films using solvent evaporation. The optimized 99.6CTS/0.4EA formulation exhibited superior mechanical strength, attributed to enhanced intermolecular interactions between CTS and EA.
These findings suggest that EA-modified CTS films hold significant potential for applications in biopolymer-based packaging, wound dressings, and biomedical materials. The incorporation of EA not only reinforces the mechanical properties of CTS films but also offers additional functional benefits, such as antimicrobial activity, making them promising candidates for sustainable and high-performance materials.

Ellagic Acid for the Preparation of Cu-Based Metal-Organic Frameworks in Uranium Extraction

Ellagic Acid for the Preparation of Cu-Based Metal-Organic Frameworks in Uranium Extraction Xin, Q., Wang, H., Hu, E., Luo, K., Lei, Z., Hu, F., ... & Wang, Q. (2025). Desalination, 118768.

Ellagic acid (EA) has emerged as a key organic ligand in the synthesis of Cu-based metal-organic frameworks (MOFs) designed for uranium (U) extraction from seawater. Given the depletion of land-based uranium resources and the environmental concerns associated with traditional mining, developing efficient adsorbents for seawater uranium recovery is crucial.
In this study, EA was utilized to form a stable complex with Cu²⁺ ions through deprotonation, leading to the formation of an ellagic acid/Cu-MOF (EM). The synthesis involved dissolving EA in a mixed solvent system containing Cu(NO₃)₂·3H₂O, acetic acid, and dimethylformamide (DMF), followed by controlled heating and centrifugation to obtain the EM structure. To enhance adsorption capacity and stability, a chitosan-modified composite (CEM) was further developed by incorporating chitosan into the EM precursor solution prior to centrifugation.
The resulting CEM material demonstrated significant potential for uranium extraction, benefiting from the strong chelating ability of EA and the high porosity of the MOF structure. This research highlights EA's role in sustainable resource recovery, providing an eco-friendly alternative for uranium sequestration from marine environments. The successful integration of EA into MOF-based materials paves the way for advanced adsorbents in environmental remediation and metal recovery applications.

Custom Q&A

What is the CAS number for Ellagic acid?

The CAS number for Ellagic acid is 476-66-4.

How does Ellagic acid appear physically?

Ellagic acid appears as cream-colored needles (from pyridine) or yellow powder. It is odorless.

What is the molecular weight of Ellagic acid?

The molecular weight of Ellagic acid is 302.19.

What is the molecular formula of Ellagic acid?

The molecular formula of Ellagic acid is C14H6O8.

What is the IUPAC name for Ellagic acid?

The IUPAC name for Ellagic acid is 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione.

What is the melting point of Ellagic acid?

The melting point of Ellagic acid is greater than 360 °C.

What is the density of Ellagic acid at 64 °F?

The density of Ellagic acid is 1.667 at 64 °F.

What is the percentage of actives in Ellagic acid?

The percentage of actives in Ellagic acid is 95%.

How is Ellagic acid typically used?

Ellagic acid is used as an antioxidant.

Can you provide the SMILES notation for Ellagic acid?

The SMILES notation for Ellagic acid is C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O.

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