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Zhou, Jiaxin, Bingbing He, and Wenjin Zou. Experimental Eye Research (2025): 110506.
Doxycycline, a broad-spectrum tetracycline antibiotic, is used for the treatment of corneal alkali burns due to its multifaceted therapeutic properties beyond antimicrobial action. This study investigated the protective role of doxycycline in corneal wound healing, particularly its impact on fibrosis and inflammation mediated through the Focal Adhesion (FA) signaling pathway.
in vitro, primary corneal fibroblasts stimulated with TGF-β1 exhibited elevated fibrotic markers, including Fibronectin and Collagen III. Doxycycline treatment at optimal concentrations significantly downregulated these markers, suggesting an inhibitory effect on fibrosis. Mechanistically, doxycycline interfered with the FA pathway, attenuating downstream profibrotic signaling cascades.
in vivo, topical administration of doxycycline eye drops effectively accelerated epithelial repair and reduced corneal opacity in a rat model of alkali-induced ocular injury. Histological analysis confirmed diminished scar formation and improved corneal architecture, supporting its therapeutic efficacy.
Furthermore, dose-dependent screening confirmed doxycycline's cellular compatibility and therapeutic window, providing a strong foundation for its clinical application. The dual capacity of doxycycline to suppress matrix metalloproteinase activity and modulate cellular adhesion signaling highlights its potential as a targeted anti-fibrotic agent.
In summary, doxycycline is used for the prevention and treatment of corneal alkali burns by modulating the FA signaling pathway, promoting epithelial healing, and preventing excessive scarring-offering a novel strategy for managing severe ocular surface injuries.
Conceição, Mariana, et al. Brain, Behavior, & Immunity-Health 42 (2024): 100894.
Doxycycline, a well-characterized tetracycline antibiotic, is being repurposed for the treatment of Alzheimer's disease (AD) due to its demonstrated anti-amyloid, anti-inflammatory, and neuroprotective properties. Although doxycycline exhibits promising effects in targeting neurodegenerative pathways, its clinical application in central nervous system (CNS) disorders is limited by poor brain bioavailability due to the blood-brain barrier (BBB).
Recent studies propose nanostructured drug delivery systems as a viable strategy to overcome this limitation. These nano-formulations improve doxycycline's pharmacokinetic profile and facilitate its transport across the BBB. Notably, in silico, in vitro, and in vivo models confirm enhanced CNS targeting via optimized nanoparticle encapsulation, ensuring controlled release and reduced systemic toxicity.
Among delivery routes, the intranasal pathway has emerged as a non-invasive and efficient alternative to conventional systemic administration, offering direct drug access to the brain. Additionally, the established safety profile of doxycycline supports its repurposing for long-term use in chronic neurodegenerative conditions.
Ongoing research aims to fine-tune the dose-response relationship and assess the therapeutic efficacy of doxycycline-loaded nanocarriers in modulating key Alzheimer's-related pathologies. These include the inhibition of amyloid-beta aggregation and attenuation of oxidative stress and neuroinflammation.
In summary, doxycycline is used for the treatment of Alzheimer's disease through nano-based delivery systems, representing a novel and promising avenue for drug repositioning in neurotherapeutics.
Chang, Hui-Fang, and Ji-Yen Cheng. Biochemistry and Biophysics Reports 38 (2024): 101690.
Doxycycline, traditionally utilized as a tetracycline-class antibiotic, is used for the inhibition of glioblastoma cell electrotaxis by modulating matrix metalloproteinase-9 (MMP-9) expression under physiological electric field (EF) conditions. This study demonstrates that U87 glioblastoma cells exhibit cathodal migration under direct current electric fields (~300 mV/mm), a behavior associated with enhanced metastatic potential.
However, treatment with non-cytotoxic concentrations of doxycycline significantly suppressed this electrotactic migration. Interestingly, doxycycline enhanced general cell motility yet disrupted directed movement toward the cathode. Mechanistically, EF exposure upregulated MMP-9 expression-an enzyme closely linked to extracellular matrix remodeling and metastasis-while MMP-2 levels remained unchanged. Co-treatment with doxycycline effectively repressed the EF-induced upregulation of MMP-9, correlating with a notable decrease in directed cell migration.
These findings suggest that doxycycline interferes with EF-guided metastatic signaling pathways in glioblastoma, likely through selective inhibition of MMP-9 expression. Although the precise molecular cascade remains to be elucidated, this study presents compelling evidence supporting the potential application of doxycycline as an anti-metastatic agent in EF-sensitive malignancies.
In summary, doxycycline is used for the inhibition of glioblastoma electrotaxis via suppression of MMP-9 activity, offering a novel therapeutic strategy for targeting cancer metastasis influenced by bioelectric cues.
What is the CAS number for Doxycycline?
The CAS number for Doxycycline is 564-25-0.
What are some synonyms for Doxycycline?
Some synonyms for Doxycycline include 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)-.
What is the molecular weight of Doxycycline?
The molecular weight of Doxycycline is 444.43.
What is the molecular formula of Doxycycline?
The molecular formula of Doxycycline is C22H24N2O8.
What is the melting point of Doxycycline?
The melting point of Doxycycline is 206-209°C (dec.).
What percentage of actives does Doxycycline contain?
Doxycycline contains 95% of actives.
In what physical state does Doxycycline exist?
Doxycycline exists in a solid physical state.
What is a typical application of Doxycycline?
A typical application of Doxycycline is the use as an antibiotic.
Can Doxycycline be used for treating bacterial infections?
Yes, Doxycycline can be used for treating bacterial infections as an antibiotic.
What are some potential side effects associated with the use of Doxycycline?
Some potential side effects associated with the use of Doxycycline include nausea, vomiting, diarrhea, and sensitivity to sunlight.
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