Cui, Weijun, et al. International Journal of Biological Macromolecules 242 (2023): 125165.
DL-Panthenol, the alcohol analog of pantothenic acid (vitamin B5), plays a crucial role in metabolic and physiological processes. Once absorbed, it is rapidly converted into pantothenic acid, an essential precursor for coenzyme A (CoA) synthesis, which is vital for fatty acid metabolism, neurotransmitter biosynthesis, and cellular energy production.
Recent studies highlight the involvement of DL-Panthenol in regulating lipid metabolism and stress response. It has been shown to modulate the secretion of anti-stress hormones, thereby supporting adrenal function. Furthermore, DL-Panthenol has immunoregulatory properties, influencing leukocyte proliferation and immune system balance.
Metabolomic analysis indicates that DL-Panthenol levels fluctuate in metabolic disorders, such as type 2 diabetes mellitus (T2DM). Research suggests that its increased presence may be linked to metabolic dysregulation, while its reduction through specific interventions could contribute to restoring homeostasis. Notably, DL-Panthenol levels have been negatively correlated with beneficial gut microbiota, including Akkermansia and Lactobacillus, suggesting a complex interaction between vitamin B5 metabolism and gut microbial composition.
Beyond metabolic health, DL-Panthenol is widely utilized in dermatological and pharmaceutical applications due to its moisturizing, wound-healing, and anti-inflammatory properties. These multifunctional roles highlight the compound's significance in both biochemical and therapeutic contexts, making it a valuable subject of ongoing research in metabolic and immune system regulation.
Bhat, Samatha, et al. Journal of Cosmetic Dermatology 21.2 (2022): 814-826.
DL-Panthenol, a derivative of pantothenic acid (vitamin B5), is increasingly recognized for its beneficial effects in cosmetic formulations. In the context of anti-aging treatments, DL-Panthenol plays a critical role in enhancing the efficacy of bioactive formulations. As an active ingredient in the development of a bioactive formulation, DL-Panthenol contributes to skin hydration, repair, and anti-inflammatory effects.
In a recent study, DL-Panthenol was incorporated into a formulation containing 10% 10× BMMSC conditioned medium (CM), antioxidants, and a range of cosmetic excipients. The formulation demonstrated enhanced anti-aging properties, with DL-Panthenol working synergistically with other ingredients like vitamin E, glycerin, and kojic acid. DL-Panthenol's inclusion improved skin texture and elasticity, while antioxidants further supported its skin-brightening and melanin-reducing effects.
The formulation was prepared by dissolving DL-Panthenol along with xanthan gum, allantoin, and other excipients, followed by the incorporation of the 10× CM. The result was a homogenous cosmetic product that exhibited promising in vitro efficacy, outperforming the CM alone in inhibiting melanin production. This highlights DL-Panthenol's significant contribution to skin care by supporting both the structural integrity of the skin and its protective functions.
What is the CAS number for DL-Panthenol?
The CAS number for DL-Panthenol is 16485-10-2.
What are some synonyms for DL-Panthenol?
Some synonyms for DL-Panthenol are Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, DL- and DL-Pantothenol.
What is the molecular weight of DL-Panthenol?
The molecular weight of DL-Panthenol is 205.25.
What is the molecular formula of DL-Panthenol?
The molecular formula of DL-Panthenol is C9H19NO4.
What is the percentage of actives in DL-Panthenol?
The percentage of actives in DL-Panthenol is 95%.
What is the physical state of DL-Panthenol?
The physical state of DL-Panthenol is liquid.
How is DL-Panthenol typically used in applications?
DL-Panthenol is typically used as a dispersing agent and emulsifying agent.
What is the purpose of using DL-Panthenol as a dispersing agent?
DL-Panthenol is used as a dispersing agent to help evenly distribute particles in a solution.
How does DL-Panthenol function as an emulsifying agent?
DL-Panthenol functions as an emulsifying agent by helping to mix together substances that typically do not blend well, such as oil and water.
Can DL-Panthenol be used in other applications besides as a dispersing agent and emulsifying agent?
Yes, DL-Panthenol may have other applications beyond being used as a dispersing agent and emulsifying agent.
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