Najafiasl, Maryam, et al. Polymer Testing 91 (2020): 106827.
Electrospun nanofibers containing panthenol (Dex) were prepared using polyethylene oxide (PVA)/sodium alginate (SA) as the core and shell materials, respectively, for wound dressing. In vivo studies on the wound dressings containing panthenol demonstrated better healing effects compared to those without panthenol.
Experimental Procedure: The solutes were dissolved in deionized water to prepare sodium alginate (2% w/v) and polyethylene oxide (10% w/v) solutions. The sodium alginate and PVA solutions were then mixed to obtain a mixture with a volume ratio of PVA to SA in the range of 80:20. The mixture was stirred for 20 hours to form a completely homogeneous solution. Triton X-100 (1% v/v) and panthenol (0.8% w/v) were then added to the PVA/SA solution as the core fluid. Chitosan was prepared at a concentration of 1% w/v in acetic acid (0.1 M) to form the shell fluid. The electrospinning process was conducted at a voltage of 20-25 kV, room temperature, and a flow rate of 0.2 mL/h. The nanofibers were collected on a stainless steel cylindrical collector covered with plastic wrap, positioned 10-12 cm away from the needle tip.
Najafiasl, Maryam, et al. Journal of Drug Delivery Science and Technology 57 (2020): 101708.
The skin acts as a barrier to prevent infections and contaminants from entering the body, and wound dressings are one of the most important tools for wound healing. The use of drugs can accelerate the healing process, and therefore, panthenol was incorporated into the polymer composition of polyethylene oxide (PVA) and sodium alginate (SA) by a blending method.
Preparation of Electrospinning Solution: The solutes were dissolved in deionized water. PVA (2% and 10% w/v) and SA (2% w/v) aqueous stock solutions were prepared by stirring at 80 °C for 3 hours with a magnetic stirrer and at room temperature for 2 hours. From the stock solution, a PVA/SA (80:20 v/v) solution was obtained and stirred for 20 hours to form a completely homogeneous solution. Next, 1% v/v Triton X-100 was added to the mixture. Finally, 0.8% w/v panthenol (Dex) was added to the solution, which formed the core fluid. Four different chitosan (CS) solutions were used as shell fluids: 1% w/v and 3% w/v acetic acid solutions of chitosan, PVA solution (2% w/v aqueous solution), and a PVA (2% w/v)/CS (1% w/v) solution (40:60 v/v).
What is the molecular formula of Dexpanthenol according to the reference?
The molecular formula of Dexpanthenol is C9H19NO4.
What is the molecular weight of Dexpanthenol according to the reference?
The molecular weight of Dexpanthenol is 205.25 g/mol.
What are some synonyms for Dexpanthenol mentioned in the reference?
Some synonyms for Dexpanthenol are D-Panthenol, Pantothenol, and D-Pantothenyl alcohol.
What is the role of Dexpanthenol mentioned in the reference?
Dexpanthenol has a role as a cholinergic drug and a provitamin according to the reference.
How is Dexpanthenol enzymatically cleaved according to the reference?
Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, according to the reference.
In what type of products is Dexpanthenol commonly used according to the reference?
Dexpanthenol is used in topical products such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing.
What are some dermatological effects of the topical use of Dexpanthenol mentioned in the reference?
Some dermatological effects of the topical use of Dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing.
What is the exact mechanism of action of Dexpanthenol mentioned in the reference?
The exact mechanism of the actions of Dexpanthenol is unclear, but it may enhance the effect of acetylcholine according to the reference.
How does Dexpanthenol act on the gastrointestinal tract according to the reference?
Dexpanthenol acts on the gastrointestinal tract and increases lower intestinal motility according to the reference.
How is Dexpanthenol applied topically to the skin according to the reference?
Dexpanthenol is applied topically to the skin to relieve itching and to promote healing according to the reference.
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