Liao, Jiahao, et al. Journal of Functional Foods 124 (2025): 106653.
D-Mannose has been effectively utilized in the design of nanoliposomes to enhance the targeted delivery of bioactive compounds to macrophages. In a recent study, D-mannose-modified nanoliposomes (MLipo@OVA) were developed to encapsulate ovalbumin (OVA), a model antigen, aiming to investigate its immunomodulatory and anti-inflammatory effects.
The nanoliposomes were formulated using a lipid mixture of DPPC, cholesterol, DSPE-PEG2000, dimethyldioctadecylammonium bromide (DDAB), mannose lipids, and α-tocopherol. A thin film hydration method was employed, followed by extrusion through a 200-nm membrane to achieve uniform nanoliposome size. D-Mannose played a crucial role in increasing macrophage uptake, thereby enhancing the bioavailability of OVA.
In vitro studies demonstrated that MLipo@OVA significantly improved macrophage internalization compared to non-mannosylated liposomes. This highlights the potential of D-mannose-functionalized nanocarriers in immunotherapy and drug delivery. By facilitating macrophage targeting, D-mannose-modified nanoliposomes offer a promising strategy for precision medicine, particularly in inflammatory and immune-related disorders.
Zhao, Wenlong, et al. Journal of Advanced Research (2024).
D-Mannose has been identified as a potent enhancer of sperm motility and fertilization capacity, particularly in asthenozoospermic sperm. Unlike D-glucose or ATP supplementation, D-mannose effectively activates the Akt/mTOR signaling pathway, improving mitochondrial function and acrosomal integrity.
In a recent study, sperm samples were pre-treated with D-mannose before in vitro fertilization (IVF) to assess its impact on fertilization success. D-Mannose bypassed glycolytic rate-limiting steps, leading to increased ATP production and enhanced sperm capacitation. Sperm treated with D-mannose exhibited superior motility and fertilization efficiency, as evidenced by a higher ratio of two-cell embryos compared to untreated samples. Confocal microscopy imaging confirmed improved mitochondrial activity, highlighting D-mannose's role in sustaining sperm energy metabolism.
These findings underscore the potential of D-mannose as a metabolic enhancer in assisted reproductive technologies (ART), offering a promising approach to improve fertilization outcomes, especially in cases of male infertility associated with poor sperm motility.
Tian, Dandan, et al. Antioxidants 12.8 (2023): 1579.
D-Mannose has been successfully utilized as a monomer for the synthesis of poly-D-mannose using a one-pot polymerization method. This approach follows a polydextrose-based preparation technique, wherein D-mannose undergoes polymerization under controlled thermal and vacuum conditions.
In the process, 30 g of D-mannose was mixed with 0.9 g of citric acid and subjected to polymerization at 155 °C under -0.1 MPa vacuum for 30 minutes. Water vapor was continuously extracted to drive the reaction forward. The resulting polymer was purified through dialysis and subsequently lyophilized to yield poly-D-mannose.
This method offers an efficient and scalable strategy for producing poly-D-mannose, a carbohydrate polymer with potential applications in biomedical and food industries. The use of citric acid as a catalyst and the vacuum-assisted approach ensure controlled polymerization, minimizing undesired byproducts. This study highlights the versatility of D-mannose in polymer chemistry, paving the way for further applications in functional polysaccharide synthesis.
What is the molecular weight of D-Mannose?
The molecular weight of D-Mannose is 180.16.
What is the boiling point of D-Mannose?
The boiling point of D-Mannose is 232.96 °C.
What is the melting point of D-Mannose?
The melting point of D-Mannose is 133-140 °C.
What is the purity of D-Mannose?
The purity of D-Mannose is 95%+.
What is the density of D-Mannose?
The density of D-Mannose is 1.539 g/cm³.
What is the appearance of D-Mannose?
The appearance of D-Mannose is white crystalline powder.
What are the typical applications of D-Mannose?
The typical applications of D-Mannose include use as an emulsion stabilizer and dispersing agent.
What are the synonyms of D-Mannose?
The synonyms of D-Mannose include 1,6-Anhydro-4-O-(2,3,4,6-tetra-O-acetyl-&alpha.
What is the physical state of D-Mannose?
The physical state of D-Mannose is a powder.
What is the CAS number of D-Mannose?
The CAS number of D-Mannose is 3458-28-4.
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