Zhang, Yansong, et al. New Journal of Chemistry 47.38 (2023): 17843-17852.
Clindamycin (CLN) is commonly used in animal and fish husbandry to promote growth, prevent infections, and treat diseases. However, clindamycin can enter the human body through contaminated foods, such as milk and meat, posing potential health risks. Therefore, detecting clindamycin in animal-derived food products, such as milk and meat, is essential. However, direct analysis of clindamycin in these samples is challenging due to its low concentration. Developing efficient pre-treatment materials for selective enrichment of clindamycin is crucial. Molecularly imprinted polymers offer a viable solution for the specific recognition and selective adsorption of target molecules. In this study, clindamycin-imprinted magnetic nanoparticles were synthesized using a boronate affinity-based oriented surface imprinting method.
Procedure:
Clindamycin-imprinted Fe3O4@FFPBA was prepared using the boronate affinity-based oriented surface imprinting technique. Initially, clindamycin templates were immobilized onto Fe3O4@FFPBA. Specifically, 120 mg of Fe3O4@FFPBA was dispersed in 20 mL of phosphate buffer solution (pH 7.0) containing clindamycin. The mixture was shaken at 25 °C for 1 hour. The resulting clindamycin-immobilized Fe3O4@FFPBA was collected and washed with 50 mM phosphate buffer solution (pH 7.0). Next, 80 mg of the clindamycin-immobilized Fe3O4@FFPBA was dispersed into 10 mL of 2-anilinoethanol solution (100 mM in pH 7.0 PBS) and shaken at 25 °C for 5 minutes. Afterward, 10 mL of 40 mM APS solution was added to the suspension, which was then sealed and shaken at 25 °C for 30 minutes. The self-polymerization of 2-anilinoethanol formed the imprinted polymer layer. The resulting CLN-imprinted Fe3O4@FFPBA was collected and washed three times with water and ethanol. Finally, the clindamycin templates were removed using 100 mM acetic acid, followed by washing with water and ethanol. For the preparation of non-imprinted magnetic nanoparticles (MNPs), the procedure was identical except for the omission of the clindamycin templates.
What is the CAS number of Clindamycin?
The CAS number of Clindamycin is 18323-44-9.
What are some synonyms for Clindamycin?
Some synonyms for Clindamycin are L-threo-alpha-D-galacto-Octopyranoside and methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-.
What is the molecular weight of Clindamycin?
The molecular weight of Clindamycin is 424.98.
What is the molecular formula of Clindamycin?
The molecular formula of Clindamycin is C18H33ClN2O5S.
What is the percentage of actives in Clindamycin?
The percentage of actives in Clindamycin is 95%.
What is the physical state of Clindamycin?
The physical state of Clindamycin is solid.
How is Clindamycin typically used?
Clindamycin is typically used as an antimicrobial agent and antibacterial agent.
What is the role of Clindamycin as an antimicrobial agent?
Clindamycin works to inhibit the growth of bacteria and is effective in treating various bacterial infections.
How does Clindamycin function as an antibacterial agent?
Clindamycin interferes with bacterial protein synthesis, leading to the inhibition of bacterial growth and reproduction.
What are some potential applications of Clindamycin?
Clindamycin can be used in the treatment of acne, skin infections, respiratory tract infections, and other bacterial infections.
CONNECT WITH US
Interested in our Services & Products ?
Need detailed information?
Terms & Conditions
Privacy Policy | Cookie Policy | Copyright © 2025 Alfa Chemistry. All rights reserved.
