Huang, Hongbin, et al. RSC advances 15.3 (2025): 1713-1720.
Caprylic/capric glycerides (GTCC) are widely recognized for their excellent solubilizing capacity and biocompatibility in cosmetic formulations. In a recent study, GTCC was effectively utilized to prepare a full-component extract of Crithmum maritimum, a coastal aromatic plant known for its rich profile of bioactive compounds, including chlorogenic acid.
Traditional extraction methods fail to capture both water- and oil-soluble constituents simultaneously, leading to suboptimal product efficacy. To overcome this, researchers developed a ternary solvent system comprising ethanol (50 wt%), GTCC (47.5 wt%), and hexanediol (2.5 wt%) to achieve comprehensive extraction. Ethanol extracted the water-soluble components, while hexanediol facilitated their retention during solvent evaporation. GTCC, due to its lipophilic nature and compatibility with polyols, was essential in solubilizing and stabilizing the full spectrum of active ingredients.
After ultrasonic-assisted cell disruption and ethanol removal via rotary evaporation, the remaining solution was filtered to yield a clear extract containing both hydrophilic and lipophilic molecules. This GTCC-based extract demonstrated superior biological activity by significantly enhancing epidermal regeneration in a UV-damaged 3D skin model, outperforming conventional oil-only extracts.
This case underscores the critical role of caprylic/capric glycerides in bridging hydrophilic-lipophilic boundaries, enabling the development of full-component botanical extracts with enhanced functional performance in dermatological and cosmetic applications.
Ye, Kai, et al. RSC Advances 6.87 (2016): 84119-84126.
Caprylic/capric glycerides (GTCC), a blend of medium-chain triglycerides, have demonstrated critical functionality in the formulation of stable fragrance nanocarriers. In a recent study, GTCC was incorporated as a co-solvent and core phase diluent in the preparation of dementiaolized peppermint (DP) fragrance nanocapsules via interfacial polymerization.
The process involved the formation of a nanoemulsion system, where GTCC was mixed with isophorone diisocyanate (IPDI) and DP fragrance to constitute the oil phase. This phase was emulsified in an aqueous sodium dodecyl sulfate (SDS) solution using ultrasonic dispersion. Subsequently, hexamethylene diamine (HMDA) was added dropwise to initiate the interfacial polymerization, resulting in polyurea-based nanocapsules encapsulating the fragrance payload.
GTCC played a vital role in modulating the viscosity and miscibility of the oil phase, facilitating the formation of uniform nanoemulsions and improving the encapsulation efficiency. Its inclusion contributed to better control over droplet size, enhanced stability of the fragrance within the capsule core, and reduced volatility.
The final nanocapsules were purified and freeze-dried to obtain powder forms with the fragrance securely encapsulated, demonstrating the effectiveness of GTCC as a functional excipient. This approach highlights the utility of caprylic/capric glycerides in designing advanced nanodelivery systems for volatile and sensitive compounds in cosmetic and fragrance applications.
Severino, Patrícia, et al. Colloids and Surfaces B: Biointerfaces 86.1 (2011): 125-130.
Caprylic/capric glycerides play a critical role in the development of lipid nanoparticles (LNPs) due to their physicochemical compatibility and stabilizing function in lipid matrices. In the formulation of solid lipid nanoparticles (SLNs), these medium-chain triglycerides are frequently blended with solid lipids such as stearic acid to optimize polymorphism, enhance stability, and enable efficient drug encapsulation.
A recent study evaluated lipid matrices comprising pure stearic acid and stearic acid-caprylic/capric glyceride mixtures (70:30) using Differential Scanning Calorimetry (DSC), Wide Angle X-ray Diffraction (WAXD), and Polarized Light Microscopy (PLM). These techniques confirmed that the binary lipid systems exhibited improved thermal behavior and reduced polymorphic transitions, critical for nanoparticle stability. The fusion and tempering processes, mimicking nanoparticle production, revealed that caprylic/capric glycerides contributed to maintaining structural integrity during thermal stress.
Additionally, hydrophilic-lipophilic balance (HLB) optimization using surfactants like polysorbate 80 and sorbitan trioleate (10:90) with the lipid mixture achieved a target HLB of 13.8, ideal for forming stable emulsions as precursors to LNPs. This emulsion stability is essential for achieving uniform particle size and long-term dispersion integrity.
This case study highlights the essential function of caprylic/capric glycerides in tailoring lipid matrices for nanoparticle synthesis, underscoring their significance in advanced drug delivery systems.
What is the CAS number for Caprylic/capric glycerides?
The CAS number for Caprylic/capric glycerides is 73398-61-5.
What are some synonyms for Caprylic/capric glycerides?
Some synonyms for Caprylic/capric glycerides are Glycerides, mixed decanoyl and octanoyl.
What is the IUPAC name of Caprylic/capric glycerides?
The IUPAC name of Caprylic/capric glycerides is 11-(2,3-dihydroxypropoxycarbonyl)heptadecanoate.
What is the density of Caprylic/capric glycerides?
The density of Caprylic/capric glycerides is 0.94-0.96g/ml.
What is the percentage of actives in Caprylic/capric glycerides?
The percentage of actives in Caprylic/capric glycerides is 95%.
In what physical state is Caprylic/capric glycerides?
Caprylic/capric glycerides is in a liquid physical state.
What are the typical applications of Caprylic/capric glycerides?
The typical applications of Caprylic/capric glycerides are as a lubricant, dispersing agent, and emulsion stabilizer.
What is the SMILES representation of Caprylic/capric glycerides?
The SMILES representation of Caprylic/capric glycerides is CCCCCCC(CCCCCCCCCC(=O)[O-])C(=O)OCC(CO)O.
What is the InChI key for Caprylic/capric glycerides?
The InChI key for Caprylic/capric glycerides is InChI=1S/C21H40O6/c1-2-3-4-10-13-18(21(26)27-17-19(23)16-22)14-11-8-6-5-7-9-12-15-20(24)25/h18-19,22-23H,2-17H2,1H3,(H,24,25)/p-1.
How can Caprylic/capric glycerides be used?
Caprylic/capric glycerides can be used as a lubricant, dispersing agent, and emulsion stabilizer.
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