Zhang, Yaping, et al. Applied Clay Science 143 (2017): 336-344.
Betamethasone dipropionate (BDP), a hydrophobic glucocorticoid, was used to construct a hierarchical nanocomposite based on layered double hydroxide (LDH) intercalation and liposomal encapsulation, aiming to improve water dispersibility and sustained-release performance.
The synthesis began with the preparation of BDP-Ch micelles. A chloroform solution of BDP (1 g/L, 25 mL) was added to an aqueous cholic acid (Ch) solution (0.02 M, 50 mL) under magnetic stirring. The mixture was stirred under nitrogen to evaporate chloroform, yielding BDP-loaded Ch micelles. Subsequently, 10 mL of LDH nanosheet (SLNS) dispersion (10 g/L) was added dropwise under stirring. After 1 h, the precipitate was collected by centrifugation, washed with CO₂-free water and ethanol, and partially freeze-dried to obtain BDP-Ch-LDH powder.
For liposomal encapsulation, the undried BDP-Ch-LDH (~0.2 g) was dispersed in 50 mL water and mixed with 100 mL chloroform containing lecithin (0.6 g) and cholesterol (0.2 g). After 10 min of ultrasonication, a milky water-in-oil emulsion formed. Chloroform was removed via rotary evaporation, forming a gel-like slurry. Upon further addition of water and sonication, a stable aqueous suspension of (BDP-Ch-LDH)@liposome was obtained, followed by freeze-drying to yield the final nanocomposite.
Elbarbary, Ahmed M., et al. Journal of Drug Delivery Science and Technology 89 (2023): 105024.
Betamethasone dipropionate (BMDP), a potent glucocorticoid for treating chronic inflammatory skin disorders, was incorporated into a novel hydrogel matrix composed of poly(acrylic acid/polyvinylpyrrolidone/2-dimethylamino ethyl methacrylate) [poly(AA/PVP/DMAEM)], synthesized via γ-irradiation to enhance drug delivery performance.
The hydrogel preparation began by dissolving 5 g of PVP in 50 mL of deionized water at 90 °C under continuous stirring, yielding a 10 wt% PVP solution. Subsequently, 10 mL of DMAEM was slowly added to 10 mL of the PVP solution under vigorous agitation. After achieving homogeneity, 10 mL of acrylic acid was introduced to the mixture while stirring continued. The resulting solution was then transferred into sealed test tubes and deaerated with nitrogen gas for 3-5 minutes.
The mixtures were subjected to γ-irradiation at doses of 10, 20, and 30 kGy (dose rate: 0.83 kGy/h) to induce crosslinking and hydrogel formation. Post-irradiation, the hydrogels were cut into discs and immersed in deionized water for 24 hours to eliminate unreacted monomers, followed by drying at 50 °C.
This hydrogel platform demonstrates significant potential as a sustained-release carrier for BMDP, offering enhanced therapeutic efficacy in topical treatment of skin inflammation.
Kong, Xin, et al. asian journal of pharmaceutical sciences 11.2 (2016): 248-254.
Betamethasone dipropionate (BD), a highly potent corticosteroid, was successfully formulated into nanostructured lipid carriers (NLCs) to enhance its therapeutic performance in treating atopic dermatitis. The BD-loaded NLCs were prepared via a melt emulsification technique followed by ultrasonication.
Initially, the lipid phase was formed by melting Precirol ATO 5 and oleic acid (3% w/v total) under gentle stirring at 85 °C. BD (0.05% w/v) was then added to this lipid melt and dissolved completely. Simultaneously, Tween 80 was dissolved in 10 mL of distilled water at the same temperature and added dropwise into the lipid phase under moderate magnetic stirring for 7 minutes, forming a coarse emulsion.
To reduce particle size to the nanometer scale, the emulsion was subjected to ultrasonication using a probe-type sonicator at 400 W for 72 seconds. The resulting nanoemulsion was rapidly cooled in an ice-water bath, promoting the formation of BD-NLCs. The final suspension volume was adjusted to 10 mL with distilled water.
This BD-NLC system offers a promising topical drug delivery platform with improved skin penetration and stability, making it particularly suitable for clinical applications in inflammatory skin disorders.
What is the CAS number for Betamethasone dipropionate?
The CAS number for Betamethasone dipropionate is 5593-20-4.
What is the IUPAC Name of Betamethasone dipropionate?
The IUPAC Name of Betamethasone dipropionate is betamethasone dipropionate.
What is the molecular weight of Betamethasone dipropionate?
The molecular weight of Betamethasone dipropionate is 504.59.
What is the boiling point of Betamethasone dipropionate?
The boiling point of Betamethasone dipropionate is 603.2ºC at 760mmHg.
What is the melting point of Betamethasone dipropionate?
The melting point of Betamethasone dipropionate is 178ºC.
What is the purity of Betamethasone dipropionate?
The purity of Betamethasone dipropionate is 97%.
What is the density of Betamethasone dipropionate?
The density of Betamethasone dipropionate is 1.24g/cm³.
What is the appearance of Betamethasone dipropionate?
The appearance of Betamethasone dipropionate is in powder form.
What are the typical applications of Betamethasone dipropionate?
The typical applications of Betamethasone dipropionate include use as an anti-inflammatory agent, emulsifying agent, dispersing agent, and lubricant.
What is the physical state of Betamethasone dipropionate?
The physical state of Betamethasone dipropionate is a solid.
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