![Preparation of Inclusion Complexes of Acyclic Cucurbit[n]urils with β-Ionone](/upload/casestudy/preparation-of-inclusion-complexes-of-acyclic-cucurbitnurils-with-b-ionone.jpg)
Wang, Lutao, et al. Journal of Molecular Structure 1310 (2024): 138275.
In this study, the thermal stability of β-ionone was enhanced by preparing inclusion complexes with acyclic cucurbit[n]urils (M1 and M2). Using fluorescence titration, the binding constants were determined, revealing a 1:1 stoichiometric ratio for the inclusion compounds. Further controlled release and thermogravimetric analyses demonstrated that these inclusion complexes exhibit exceptional thermal stability.
Preparation of ACBs(M1, M2)/β-Ionone Inclusion Complexes
The β-ionone inclusion complexes with ACBs (M1, M2) were prepared using freeze-drying and a saturated aqueous solution method. β-Ionone was added to the saturated ACBs solution in a 1:1 molar ratio and allowed to stir in the dark at room temperature for three days. The reaction mixture was then filtered through a 0.45 μm Millipore membrane, and the filtrate was freeze-dried to yield a white solid.
Sihag, Monika, et al. European Journal of Medicinal Chemistry Reports 12 (2024): 100204.
In this study, pyrazole and pyrazoline derivatives of β-ionone were synthesized through different methodologies. The first approach involved the intramolecular oxidative C-H amination of hydrazone, resulting in the formation of pyrazole derivatives in moderate to good yields. Another method utilized the condensation of hydrazine hydrochloride with β-ionone in methanol, leading to the formation of pyrazoline. This pyrazoline intermediate was then subjected to oxidative dehydrogenation using a hypervalent iodine reagent, converting it into the corresponding pyrazole. Additionally, a one-pot synthesis route was developed by refluxing hydrazine hydrochloride with β-ionone in acetic acid, enabling the direct formation of pyrazole.
Liu, Yunshan, and Jianzhong Jiang. Carbohydrate Polymers 312 (2023): 120839.
β-Ionone, known for its unique violet odor and biological activity, is a promising fragrance compound and potential anticancer agent. This study explores the microencapsulation of β-ionone using a complex coacervation technique, combining gelatin and pectin as wall materials. The biopolymer solutions were prepared by dissolving gelatin and pectin in deionized water, followed by centrifugation to remove impurities. The pH of the pectin solution was adjusted to prevent electrostatic complexation during the premixing process.
A 3:1 (w/w) gelatin/pectin ratio was used to create the coacervates, with β-ionone added in a 1:1 (w/w) core-to-wall ratio. The system was then stirred and homogenized before being subjected to crosslinking using glutaraldehyde, followed by freeze-drying at -48 °C for 48 hours to produce dry microcapsules.
This method successfully encapsulated β-ionone, providing a stable and controlled release system. The microencapsulation of β-ionone enhances its potential applications, including its use as an anticancer drug, by ensuring the stability and bioavailability of the active compound. The study offers valuable insights into the formulation of β-ionone for targeted delivery systems in pharmaceutical and cosmetic industries.
What is the CAS number of Beta-Ionone?
The CAS number of Beta-Ionone is 14901-07-6.
What are some synonyms for Beta-Ionone?
Some synonyms for Beta-Ionone are 3-Buten-2-one and FEMA No. 2595.
What is the molecular weight of Beta-Ionone?
The molecular weight of Beta-Ionone is 192.3.
What is the molecular formula of Beta-Ionone?
The molecular formula of Beta-Ionone is C13H20O.
What is the melting point of Beta-Ionone?
The melting point of Beta-Ionone is -49°C.
What is the flash point of Beta-Ionone?
The flash point of Beta-Ionone is 122°C.
What is the density of Beta-Ionone?
The density of Beta-Ionone is 0.944.
What is the appearance of Beta-Ionone?
The appearance of Beta-Ionone is a clear to light yellow liquid with an odor of violets.
What is the percentage of actives present in Beta-Ionone?
Beta-Ionone contains 95% actives.
What are the typical applications of Beta-Ionone?
Beta-Ionone is typically used as a perfume.
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