Sarsam, Wail Sami, et al. International Communications in Heat and Mass Transfer 89 (2017): 7-17.
By treating multi-walled carbon nanotubes (MWCNTs) with β-alanine, the hydrophobic nature of the MWCNTs with different outer diameters was converted to hydrophilic, resulting in the preparation of covalently functionalized nanomaterials. The synthesized ala-MWCNTs exhibited high dispersibility in the base liquid.
Synthesis of ala-MWCNTs
The one-pot functionalization mechanism of MWCNTs with β-alanine involves forming a semi-stable diazonium ion and initiating a radical reaction with the surface and caps of MWCNTs. In a typical experiment, 400 mg of β-alanine was sonicated in 20 mL of DMA at 60 °C for 2 hours. Subsequently, 200 mg of pristine MWCNTs, 100 mg of NaNO2, and 0.5 mL of HCl were added, followed by 15 minutes of sonication. HCl was added dropwise to avoid side reactions. The mixture was then subjected to ultrasonic treatment for 24 hours in an ultrasonic bath. The reaction temperature was maintained at 80 °C using an oil bath. The resulting alanine-treated MWCNT (ala-MWCNT) samples were then cooled to room temperature, centrifuged, and thoroughly washed. The functionalized MWCNTs were washed multiple times with DMF, ethanol, and acetone to remove any unreacted materials and then dried at 60 °C for 96 hours.
Bozorgi, Pantea, Leila Naji, and Solmaz Valizadeh. Colloids and Surfaces A: Physicochemical and Engineering Aspects 687 (2024): 133562.
The potential enhancement effect of graphene oxide (GO) functionalized with β-alanine (βA) amino acid as a thin-film nanocomposite (TFN) membrane was explored.
Using a simple one-step method, GO nanosheets were crosslinked with the heterobifunctional molecule βA. Several GO and βA-GO based TFN membranes were prepared by varying the content of GO and βA-GO in the polyamide (PA) selective layer. Their physicochemical properties, desalination performance, and antifouling properties were compared with those of the original PA-based thin-film composite membrane (TFC). The surface morphology of the TFN membranes was smoother, and the thickness was lower compared to the TFC, with the βA-GO containing membranes exhibiting even thinner and smoother surfaces. The optimal βA-GO based TFN membrane contained 0.05 wt% βA-GO and exhibited excellent pure water flux of 22.65 L/m²h at 7.5 bar, with Na₂SO₄ and NaCl retention rates of 93.06% and 91%, respectively, significantly higher than the GO-based TFN membranes. TFN membranes containing GO and βA-GO showed more desirable antifouling properties, with the optimal βA-GO based TFN membranes displaying significantly higher reversible fouling rates of 65% and flux recovery rates of 87.6%, attributed to their smoother surface morphology. The results indicated that using βA as a crosslinking agent could control the interlayer spacing (d-spacing) of GO nanosheets in aqueous media and enhance the retention performance of PA/βA-GO TFN membranes.
Meenukutty, M. S., Arsha P. Mohan, V. G. Vidya, and VG Viju Kumar. Heliyon 8, no. 6 (2022).
Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA-dependent enzyme that belongs to the ADP-ribosyl transferase family. Although some PARP inhibitors have therapeutic applications in cancer treatment and play a crucial role in the response to DNA damage, a novel Schiff base, (E)-3-((5-bromo-2-hydroxybenzylidene)amino)propanoic acid [SBL], was synthesized using 5-bromosalicylaldehyde and β-alanine. SBL has shown potential as a promising candidate drug against breast cancer.
Synthesis of the Schiff Base
The Schiff base, (E)-3-((5-bromo-2-hydroxybenzylidene)amino)propanoic acid, is synthesized through the condensation reaction between 5-bromosalicylaldehyde and β-alanine. Each organic compound was dissolved in ethanol in a beaker at a 1:1 molar ratio. The solutions from the two beakers were then combined into a round-bottom (RB) flask and refluxed for approximately 4 hours. The resulting white compound was collected, filtered, recrystallized from ethanol, dried, and characterized.
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