Ivanova, N., Ermenlieva, N., & Andonova, V. (2024). Cosmetics, 11(5), 173.
This study explores the potential of α-bisabolol as a bioactive agent incorporated into micellar systems for cosmetic facial hygiene applications, focusing on its cleansing and antimicrobial properties. α-Bisabolol, a sesquiterpene alcohol known for its soothing and antibacterial effects, was formulated using Poloxamer 407-a nonionic triblock copolymer widely used in cosmetic formulations for its biocompatibility and solubilizing capabilities.
A 5% micellar solution of Poloxamer 407 served as the carrier system due to its favorable characteristics, including gentle washing ability, ease of application, and dermal tolerability. The solubilization efficiency of α-bisabolol was evaluated using both direct solubilization and the film hydration method at three concentrations: 0.5%, 1.0%, and 1.5%.
In the direct solubilization method, a cold-prepared 20% Poloxamer 407 concentrate was used as the primary medium, into which α-bisabolol was introduced under continuous stirring. This mixture was subsequently diluted and homogenized to achieve a stable micellar dispersion. A non-loaded 5% Poloxamer 407 solution was prepared as a control for comparative analysis.
The resulting bisabolol-loaded micellar formulations highlight the suitability of Poloxamer 407 for developing non-irritating, effective delivery systems for hydrophobic cosmetic actives such as α-bisabolol, paving the way for novel facial hygiene products with added antimicrobial benefits.
Dos Santos, Quesia Nery, et al. Experimental Parasitology 265 (2024): 108808.
This study demonstrates the development of α-bisabolol-loaded microemulsions (MEs) aimed at enhancing topical delivery for the treatment of cutaneous leishmaniasis (CL). The microemulsion systems were constructed using α-bisabolol as the oil phase, Eumulgin® CO 40 as surfactant, Polymol® HE as co-surfactant, and distilled water as the aqueous phase. Pseudoternary phase diagrams guided the selection of transparent, stable liquid systems (TLS), with F5E25 and F5EP25 emerging as optimal formulations containing 5% α-bisabolol.
The preparation process involved homogenizing a 1:1 surfactant/co-surfactant (T/CoS) mixture at 500 rpm for 24 hours, followed by incorporation of α-bisabolol and continued stirring at 100 rpm for 30 minutes. Deionized water was then added gradually under continued agitation to yield transparent dispersions. After five days, stable MEs were selected for characterization and further assays.
These formulations exhibited nanometric particle sizes (<25 nm), isotropy, and favorable pH (6.5-6.9), indicating suitability for skin application. Franz cell diffusion studies revealed a 2.5-fold increase in both skin flux and permeation of α-bisabolol compared to the free compound. ATR-FTIR analysis showed disruption of the stratum corneum lipid-protein matrix, enhancing drug partition and diffusion. Notably, the MEs displayed significantly improved antileishmanial activity, with up to 50-fold increased potency and a higher selectivity index than unencapsulated α-bisabolol. These results suggest the developed systems are promising candidates for future in vivo CL therapy.
Kim, Sangwoo, et al. Antioxidants 12.1 (2023): 207.
This case study presents the encapsulation of α-bisabolol (ABS), a natural antioxidant and antibacterial agent, into amphiphilic polymer-based nanoparticles to overcome its inherent water insolubility and enhance its application in bio-industrial formulations.
The ABS-loaded nanoparticles (ABS@NPs) were fabricated using polyglyceryl-4 caprate as the encapsulating matrix through a self-assembly process in an aqueous environment. Initially, ABS (1-8 mg) and polyglyceryl-4 caprate (20 mg) were co-dissolved in 1 mL of tetrahydrofuran (THF) under magnetic stirring at room temperature for 2 hours. The homogeneous organic phase was then introduced dropwise into 5 mL of deionized water under continuous stirring (530 rpm) using a syringe pump, promoting the formation of nanoparticles through solvent displacement.
Post-formation, the system was further stabilized by stirring at 530 rpm for 1 hour, followed by complete removal of THF via vacuum evaporation over 2 hours. The final volume was adjusted to 5 mL with DI water. The resulting nanoparticles, denoted as ABS@NP × wt%, correspond to ABS loadings of 5, 10, 20, and 40 wt% relative to the polymer.
This approach demonstrates a facile and scalable method for preparing aqueous-stable α-bisabolol delivery systems, providing a promising strategy for incorporating hydrophobic bioactives into bioproducts with enhanced solubility and functional performance.
What is the chemical name of the product?
The chemical name of the product is Alpha,4-Dimethyl-alpha-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol.
What is the CAS number of the product?
The CAS number of the product is 515-69-5.
What are the synonyms for the product?
The synonyms for the product are Alpha-Bisabolol and Bisabolol.
What is the molecular weight of the product?
The molecular weight of the product is 222.37.
What is the molecular formula of the product?
The molecular formula of the product is C15H26O.
What is the percentage of actives in the product?
The product has 95% actives.
What is the physical state of the product?
The physical state of the product is liquid.
What are the typical applications of the product?
The product is used as an antibacterial agent.
How many carbon atoms are there in the molecular formula of the product?
There are 15 carbon atoms in the molecular formula of the product.
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