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Mahmood, Othman Haji, Ali Ugur, and Arife Gencer Imer. Journal of Physics and Chemistry of Solids 184 (2024): 111733.
Brilliant Blue-FCF (BB-FCF) serves as an effective functional dye for enhancing photodetection properties in sol-gel-based thin-film devices. Its integration into Cu/BB-FCF/n-Si architectures allows for improved optical absorption, efficient charge transport, and rapid photoresponse under variable illumination, demonstrating its potential in optoelectronic and photonic applications.
Application and Experimental Overview:
A 0.2 M BB-FCF precursor solution was prepared in methyl alcohol and ultrasonicated for 15 min to ensure homogeneity. Ohmic contacts were first fabricated by depositing gold (Au) on pre-cleaned n-type silicon wafers via thermal evaporation, followed by heat treatment at 570 °C for 3 min. The BB-FCF solution was then spin-coated at 2000 rpm for 1 min on both soda-lime glass and the Au/n-Si substrate to form thin films for optical and device applications. The front contact was completed by thermally evaporating copper (Cu) onto the BB-FCF/n-Si interface, finalizing the Cu/BB-FCF/n-Si photodetector. Reference Cu/n-Si devices were fabricated under identical conditions to evaluate the impact of the BB-FCF interlayer.
Performance Characteristics:
UV-Vis spectroscopy confirmed strong optical absorption in the 350-700 nm range, with an indirect band gap of 1.72 eV. The Cu/BB-FCF/n-Si device exhibited enhanced photodetection performance compared to the reference, achieving rapid on/off switching with rising and falling times of 524 ms and 629 ms, respectively. Key figures of merit-including photoresponsivity, detectivity, and linear dynamic range-were significantly improved, demonstrating the dye's ability to facilitate efficient charge transfer and stable, reproducible photoresponse.
This case study underscores the applicability of Brilliant Blue-FCF as a versatile functional material in high-performance organic/inorganic hybrid photodetectors for advanced optoelectronic technologies.
Wdowiak, Mateusz, et al. Biofilm (2025): 100286.
Brilliant Blue FCF (BB-FCF) is demonstrated as an effective photoprotective agent for bacteriophages, enabling their application under ultraviolet (UV) irradiation conditions where traditional phage treatments fail. Its selective binding to virions preserves phage viability while allowing simultaneous inactivation of bacteria, offering a promising approach for eco-friendly disinfection in agriculture, food processing, and industrial biofouling control.
Application and Experimental Overview:
T4 bacteriophages were exposed to a UV dose of ~360 mJ/cm², which completely inactivated virions in the absence of stabilizers. BB-FCF was then introduced, resulting in near-complete preservation of non-enveloped phages, whereas Gram-negative bacteria remained susceptible to UV. The protective mechanism relies on selective adsorption of BB-FCF to the proteinaceous surface of the virions, preventing UV-induced deactivation without affecting DNA directly. Comparative studies with other dyes, including tartrazine, quinoline yellow, and Congo red, confirmed that only BB-FCF and structurally similar dyes conferred effective phage stabilization, highlighting the importance of protein-dye interactions in photoprotection.
Performance and Implications:
The synergistic use of BB-FCF-stabilized bacteriophages with UV treatment achieved up to 99.99 % bacterial removal within 30-60 min. This method enables the safe and efficient application of phages in UV-rich environments, such as sunlight-exposed agricultural fields and membrane filtration systems, without compromising phage functionality. The study illustrates BB-FCF's potential as a robust, food-grade additive for enhancing the stability and efficacy of biological control agents against microbial contamination.
This case underscores BB-FCF as a versatile chemical agent for innovative, environmentally friendly antimicrobial strategies, expanding the practical deployment of bacteriophage-based technologies.
Hocking, Kyle M., et al. Journal of vascular surgery 64.1 (2016): 210-218.
Brilliant Blue FCF (FCF) has emerged as a nontoxic dye alternative for surgical marking of vein grafts, offering both physiologic preservation and potential therapeutic benefits. Unlike conventional markers containing gentian violet and isopropanol, which induce tissue injury and compromise graft function, FCF demonstrates biocompatibility while mitigating preparation-induced vascular damage.
Application and Experimental Overview:
Porcine saphenous veins (PSV) were utilized to evaluate the protective effects of FCF during surgical preparation. Muscle bath studies assessed contractile responses and intracellular calcium fluxes in response to agonists and inhibitors, using both rat aorta and human saphenous vein samples. Cytotoxicity of FCF was evaluated in human umbilical venous smooth muscle cells, confirming its non-toxic profile. Organ culture experiments of PSV assessed the development of intimal hyperplasia, a primary contributor to graft failure.
Findings and Implications:
FCF treatment preserved vascular physiologic responses and significantly inhibited injury-induced intimal hyperplasia in vitro. The dye's nontoxicity, combined with its protective effect against cellular and tissue injury, suggests that FCF can replace off-label surgical skin markers for vein graft preparation. This approach reduces graft damage while potentially improving long-term graft patency.
The study highlights FCF not only as a safe marking agent but also as a candidate for therapeutic intervention during vascular surgeries. Further in vivo investigations are warranted to elucidate its mechanisms and optimize clinical protocols. This case underscores Brilliant Blue FCF as a promising chemical agent for enhancing surgical outcomes and preserving vascular tissue integrity.
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