Li, Peiqi, et al. Toxicology and Applied Pharmacology 482 (2024): 116788.
Acetyl triethyl citrate (ATEC) is a plasticizer commonly used in pharmaceutical products and food packaging as a non-phthalate ester alternative. Due to its direct human contact and the high leakage rate from polymers, it is crucial to assess the potential health risks of ATEC at environmentally relevant low doses.
Male C57BL/6J mice were fed a diet containing ATEC at doses of 0.1 or 10 μg/kg per day for 12 weeks, to simulate realistic exposure scenarios. The study results indicated that ATEC exposure in C57BL/6J mice led to increases in body weight, body fat percentage, as well as the size of benign hepatocytes and adipocytes. Consistent with the in vivo model, ATEC treatment significantly stimulated an increase in lipid load within mouse and human hepatocytes. Mechanistically, ATEC induced the transcriptional expression of genes involved in de novo lipogenesis and lipid absorption.
Kim, Hyeon, et al. Pharmaceutics 11.4 (2019): 162.
Acetyl triethyl citrate (ATEC) is a water-soluble plasticizer used in pharmaceutical plastic polymers. The pharmacokinetics and metabolism of ATEC in rats were studied using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
After intravenous administration of 10 mg/kg and oral administration of 500 mg/kg doses of ATEC to rats, the concentration of ATEC in plasma rapidly declined and became undetectable after 0.5 hours and 6 hours, respectively. The volume of distribution (Vz) was 4.8 L/kg, which is higher than the volume of body water, suggesting possible distribution into extravascular spaces. The absolute bioavailability (F) of ATEC was 14.8%. This relatively low F value indicates poor absorption of ATEC in the gastrointestinal tract, degradation within the intestine, and significant first-pass effects.
After intravenous administration, ATEC was rapidly eliminated, with an apparent terminal half-life of 0.03 hours and a mean residence time of 0.03 hours, while for oral ATEC, the apparent terminal half-life was 1.03 hours and the mean residence time was 6.56 hours.
What is the CAS number of Acetyltriethyl citrate?
The CAS number of Acetyltriethyl citrate is 77-89-4.
What are some synonyms for Acetyltriethyl citrate?
Some synonyms for Acetyltriethyl citrate are Triethyl O-acetylcitrate and ATEC.
What is the IUPAC name of Acetyltriethyl citrate?
The IUPAC name of Acetyltriethyl citrate is Triethyl 2-acetyloxypropane-1,2,3-tricarboxylate.
What is the molecular weight of Acetyltriethyl citrate?
The molecular weight of Acetyltriethyl citrate is 318.32.
What is the molecular formula of Acetyltriethyl citrate?
The molecular formula of Acetyltriethyl citrate is C14H22O8.
What is the boiling point of Acetyltriethyl citrate?
The boiling point of Acetyltriethyl citrate is 228-229 °C at 100mmHg.
What is the melting point of Acetyltriethyl citrate?
The melting point of Acetyltriethyl citrate is -42 °C.
What is the density of Acetyltriethyl citrate?
The density of Acetyltriethyl citrate is 1.136g/ml.
What are some typical applications of Acetyltriethyl citrate?
Some typical applications of Acetyltriethyl citrate are its use as a plasticizer, dispersing agent, emulsion stabilizer, and lubricant.
What is the percentage of actives in Acetyltriethyl citrate?
The percentage of actives in Acetyltriethyl citrate is 95%.
CONNECT WITH US
Interested in our Services & Products ?
Need detailed information?
Terms & Conditions
Privacy Policy | Cookie Policy | Copyright © 2024 Alfa Chemistry. All rights reserved.
PAGE TOP
