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Acetaminophen

Catalog Number

ACM103902-3

CAS

103-90-2

Structure

IUPAC Name

N-(4-Hydroxyphenyl)acetamide

Synonyms

Paracetamol

Molecular Weight

151.16

Molecular Formula

C8H9NO2

Canonical SMILES

CC(=O)NC1=CC=C(C=C1)O

InChI

InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI Key

RZVAJINKPMORJF-UHFFFAOYSA-N

Boiling Point

273.17 °C

Melting Point

168-172 °C(lit.)

Flash Point

11 °C

Purity

99%

Density

1.293 g/cm³

Solubility

Very slightly soluble in cold water

Appearance

Solid

Storage

Inert atmosphere, room temperature

Active Content

95%

Physical State

Solid

Typical Applications

Use as dispersingagent.
Use as hydrogen peroxide stabilizer.
Use as intermediate.

MSDS

Download MSDS

COA

Download COA

Spec Sheet

Download Spec Sheet

Case Study

Direct One-Pot Synthesis of Propofol from Paracetamol Tablets

Messina, L. C., de Espindola, C. S., & Omori, A. T. (2023). Direct One-Pot Synthesis of Propofol from Paracetamol Tablets. ACS Sustainable Chemistry & Engineering, 11(5), 1638-1642.

The COVID-19 pandemic has significantly impacted global healthcare, leading to shortages of essential drugs, including propofol. In response, various protocols for propofol synthesis have been proposed in recent years. In this study, we present a novel process that utilizes paracetamol (also known as acetaminophen), a widely available and commonly used active pharmaceutical ingredient, as the starting material. By performing the initial three steps-Friedel-Crafts double alkylation, acetyl deprotection, and diazotization-in acidic media, we developed an efficient one-pot synthesis approach for propofol.

Custom Q&A

What is the molecular weight of Acetaminophen?

The molecular weight of Acetaminophen is 151.16.

What is the molecular formula of Acetaminophen?

The molecular formula of Acetaminophen is C8H9NO2.

What is the physical state of Acetaminophen?

The physical state of Acetaminophen is solid.

What are the typical applications of Acetaminophen?

The typical applications of Acetaminophen include use as a dispersing agent, use as a hydrogen peroxide stabilizer, and use as an intermediate.

What is the percentage of actives in Acetaminophen?

The percentage of actives in Acetaminophen is 95%.

What is the CAS number of Acetaminophen?

The CAS number of Acetaminophen is 103-90-2.

Can Acetaminophen be used as a dispersing agent?

Yes, Acetaminophen can be used as a dispersing agent.

In what form does Acetaminophen come in?

Acetaminophen comes in a solid form.

What property of hydrogen peroxide does Acetaminophen help stabilize?

Acetaminophen helps stabilize hydrogen peroxide.

How does Acetaminophen function as an intermediate?

Acetaminophen can serve as an intermediate in various chemical reactions.

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