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Li, N., Jia, W., Zhang, Y., Tan, F., & Zhang, J. (2011). International journal of pharmaceutics, 415(1-2), 169-174.
1,2-Hexanediol is increasingly recognized for its multifunctionality in topical formulations, acting not only as a humectant and preservative but also as a modulator of percutaneous drug delivery. In a recent in vitro study using Franz Diffusion Cells with hairless mouse skin, 1,2-hexanediol-when combined with 1,4-cyclohexanediol-demonstrated a synergistic effect in reducing the transdermal flux of metronidazole (MTZ), a model topical drug.
Formulations containing this binary diol system significantly reduced MTZ percutaneous absorption compared to control gels, as evidenced by lower flux values and retardation ratios (RRs of 0.40 and 0.69 for 375 μg and 750 μg doses, respectively). Notably, this retardation did not affect drug retention in the epidermal and dermal layers, maintaining comparable levels to control formulations (p > 0.05). This implies that 1,2-hexanediol, in concert with 1,4-cyclohexanediol, reduces systemic exposure risk while preserving localized therapeutic efficacy.
Mechanistically, the retardant effect may arise from modulation of stratum corneum lipid packing or changes in solvent polarity within the gel matrix. All formulations maintained similar rheological properties (\~50 cp), ensuring consistent topical application characteristics.
These findings suggest that **1,2-hexanediol is highly effective for use in the preparation of topical drug delivery systems aimed at minimizing systemic absorption while sustaining dermal retention**, supporting its application in safer and more efficient dermatological therapies.
Wang, Jinping, et al. Journal of nanoparticle research 16.7 (2014): 2505.
1,2-Hexanediol (Hed) has demonstrated significant promise as a functional excipient in the design of advanced lipid-based nanocarriers for topical drug delivery. In a recent study, Hed was employed as a skin-targeting modifier in the preparation of modified nanovesicles aimed at improving the dermal delivery of ketoconazole (KCZ), an antifungal agent. These vesicles were fabricated using soy phospholipids and aqueous solutions containing varying concentrations of Hed, with conventional liposomes serving as controls.
The resulting Hed-modified nanovesicles exhibited favorable physicochemical characteristics, including a narrow size distribution (58-147 nm), good colloidal stability, and high KCZ entrapment efficiency (up to 75%). Both in vitro (newborn pig skin) and in vivo (rat skin) experiments demonstrated significantly enhanced deposition of KCZ in the skin strata, while minimizing systemic absorption. Confocal laser scanning microscopy confirmed the localized skin delivery, attributed to the synergistic interaction between the phospholipid bilayer and Hed molecules, which likely alters membrane fluidity and enhances skin permeability.
Importantly, histological evaluations showed no signs of irritation, indicating the biocompatibility of Hed-modified vesicles. These findings suggest that 1,2-hexanediol is an effective targeting modifier for the preparation of nanovesicles with improved skin retention and reduced transdermal permeation, making it an ideal component in the formulation of topical antifungal therapies.
Lajin, Bassam, Joerg Feldmann, and Walter Goessler. Analytical Chemistry 94.24 (2022): 8802-8810.
1,2-Hexanediol has recently emerged as a powerful eluent modifier in high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS), overcoming the long-standing limitations posed by conventional organic solvents. Traditionally, ICP-MS detection suffers from severe signal suppression when high levels of organic solvents are present, necessitating a specialized "organic mode" that often reduces sensitivity by up to 100-fold. In contrast, 1,2-hexanediol enables high organic solvent tolerance under standard ICP-MS conditions, even at flow rates up to 1.5 mL·min⁻¹ and concentrations as high as 30% v/v.
When used as an eluent additive, 1,2-hexanediol not only improves plasma compatibility but also enhances the detection sensitivity for key nonmetals (P, S, Cl, Br, Se, As) by 1.5-7 times compared to fully aqueous systems. Its superior elution strength allows efficient separation and quantification of highly hydrophobic analytes, such as lipids and arsenic-containing fatty acids, at ultra-trace levels-achieving detection limits below 0.01 μg As·L⁻¹ in complex biological matrices like human urine.
Furthermore, its application in nontargeted metabolomics revealed rich sulfur-containing compound profiles in garlic extract (Allium sativum), underscoring its utility in elemental speciation analysis. Thus, **1,2-hexanediol is a superior eluent component for preparing ICP-MS-compatible mobile phases**, especially for trace-level detection in complex matrices without compromising analytical performance.
What is the product name of CAS number 6920-22-5?
The product name is 1,2-Hexanediol.
What is the molecular weight of 1,2-Hexanediol?
The molecular weight is 118.17.
What is another name for 1,2-Hexanediol?
Another name for 1,2-Hexanediol is 1,2-Dihydroxyhexane.
What is the molecular formula of 1,2-Hexanediol?
The molecular formula is C6H14O2.
What is the percentage of actives in 1,2-Hexanediol?
The percentage of actives is 95%.
What is the physical state of 1,2-Hexanediol?
The physical state is liquid.
What are some typical applications of 1,2-Hexanediol?
Some typical applications include use as a solvent, use as an intermediate in organic synthesis, and use as a lubricant.
Can 1,2-Hexanediol be used as a solvent?
Yes, 1,2-Hexanediol can be used as a solvent.
Is 1,2-Hexanediol used in organic synthesis?
Yes, 1,2-Hexanediol is used as an intermediate in organic synthesis.
What is the CAS number of 1,2-Hexanediol?
The CAS number is 6920-22-5.
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