Zhao, J., Hu, J., & Ma, X. (2021). Nutrients, 13(8), 2756.
This study investigates the application of sodium decanoate (SD) in improving intestinal barrier integrity and antioxidant defense in both IPEC-J2 cells and C57/BL6 mice models. SD, a medium-chain fatty acid salt, was evaluated for its ability to mitigate oxidative stress induced by H2O2 and to enhance gut physiological functions.
In vitro experiments revealed that SD at 1 mmol/L upregulated tight junction protein expression in IPEC-J2 cells, effectively reinforcing cellular barrier function. Additionally, SD improved the antioxidant capacity of cells under oxidative stress conditions, as indicated by enhanced scavenging activity and reduced oxidative damage. Comparative analysis with sodium butyrate confirmed the superior efficacy of SD in these protective roles.
In vivo, SD administration significantly increased ileal villus height, improved intestinal morphology, and enhanced growth performance of mice. Moreover, SD modulated gut microbiota by increasing α-diversity and promoting the production of volatile fatty acids. Mechanistic investigations indicated that these benefits were mediated via activation of the G protein-coupled receptor-43 (GPR-43) signaling pathway in the ileum and colon, linking SD supplementation to improved intestinal barrier and metabolic signaling.
Overall, this work establishes sodium decanoate as a multifunctional agent for enhancing intestinal health, promoting growth, and mitigating oxidative stress. Its dual action-strengthening the epithelial barrier and activating GPR-43-mediated antioxidant pathways-highlights its potential application in animal nutrition and functional food development.