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Wang, Huaidong, et al. Results in Chemistry 15 (2025): 102208.
Gellan gum (GG), a microbial polysaccharide, was effectively utilized as a biocompatible matrix for preparing a nanocomposite scaffold aimed at bone tissue repair. This study highlights the use of gellan gum in forming a freeze-dried nano-hydroxyapatite@gellan gum (nHA@GG) scaffold with desirable structural and biological features for regenerative medicine.
To fabricate the scaffold, nano-hydroxyapatite (nHA) was first dispersed in distilled water, stirred for 4 hours, and sonicated to ensure homogeneous nanoparticle distribution. A mixture containing 1 g of gellan gum, 5 mL of 0.1 M CaCl₂, and 0.5 g of glycerol was then added. The gellan gum served as the structural backbone, while CaCl₂ and glycerol functioned as cross-linking and plasticizing agents, respectively. The solution was continuously stirred at 70 °C for 2 hours to facilitate gelation.
The resulting gel was washed with deionized water to remove unreacted polymers and subjected to freeze-drying at -80 °C for three days. This process yielded a porous, lightweight scaffold with a well-integrated nHA network. Finally, the scaffold was conditioned at 25 °C and 50% RH for 48 hours to stabilize its structure for further analysis.
This case study demonstrates gellan gum's suitability in constructing mechanically stable, bioactive scaffolds for advanced bone tissue engineering applications.
Tu, Wenyao, et al. Food Hydrocolloids (2025): 111514.
Gellan gum (GG), a naturally derived polysaccharide, was effectively employed alongside sodium alginate (SA) to construct core-shell microcapsules through a controlled double emulsion microfluidic technique. This approach targets the encapsulation of hydrophobic compounds for food and pharmaceutical applications, leveraging the gel-forming ability of GG in the presence of calcium ions.
To prepare the shell material, 1% (w/w) GG and SA were individually dissolved in deionized water and heated at 80 °C under stirring. Various SA\:GG ratios (9:1 to 1:9) were explored to evaluate compatibility and gelation efficiency. The resulting blends were crosslinked in 5% (w/w) CaCl₂ to form SA/GG-Ca²⁺ gels.
Double emulsions were generated using a custom coaxial capillary microfluidic device, where the inner phase was soybean oil (dyed with Sudan III), the middle phase was SA/GG solution containing 2% Tween 80 and 0.1% CaCO₃, and the outer phase was acetic acid-containing oil. Flow rates were finely controlled via pressure regulators to achieve stable emulsion droplets.
The emulsions were then solidified in CaCl₂ solution for 3 hours, washed with n-octane to remove surface oil, and air-dried at 25 °C, yielding uniform microcapsules.
This study highlights gellan gum's exceptional performance in forming biocompatible, thermally stable microcapsule shells suitable for encapsulating sensitive actives using double emulsion templating.
Shahzad, Sana, Ikram Ullah Khan, and Ikrima Khalid. International Journal of Biological Macromolecules 308 (2025): 142493.
Gellan gum (GG), a naturally occurring biopolymer, was successfully employed as a matrix material for the preparation of α-mangostin (α-MG)-loaded hydrogel membranes designed for wound healing applications. Owing to its excellent gel-forming ability and biocompatibility, GG served as the structural base for incorporating α-MG, a bioactive xanthone known for its potent antibacterial, antioxidant, and anti-inflammatory properties.
The hydrogel membranes were fabricated via a solvent casting and ionic crosslinking method. GG was dissolved in distilled water (0.5% or 1% w/v) at 50 °C under stirring, followed by the addition of propylene glycol (15% w/w relative to GG) as a plasticizer. Separately, α-MG was dissolved in ethanol with 0.2% Tween 80 (w/w of α-MG) and added to the GG solution to ensure uniform dispersion. The resulting homogeneous mixture was cast into petri dishes and allowed to cool to room temperature. To induce crosslinking, a 0.5% calcium chloride solution was sprayed over the surface to establish ionic bridges between the polymer chains.
The crosslinked films were dried and stored in desiccators, yielding flexible hydrogel membranes. This method effectively enhances the solubility and bioavailability of α-MG while providing a moist, protective interface for wound sites, making gellan gum a valuable material in the development of next-generation wound dressings.
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