Takagi, Yutaka. Journal of Clinical Medicine. 2024;13(6):1749.
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with skin itching, impaired skin barrier function, and water-holding capacity impairment. The levels of ceramide in the stratum corneum of AD patients are reduced. Ceramide is the main component of intercellular lipids and is crucial for its function. Treatments that increase ceramide levels are effective in AD care. Synthetic pseudoceramide (cetyl PG hydroxyethyl palmitamide (SLE66)), with a structure developed through molecular design, and eucalyptus leaf extract (ELE) promote epidermal ceramide synthesis. Topical application of skin moisturizers containing SLE66 and ELE can improve the barrier function and water retention capacity of AD skin while improving skin symptoms.
The Efficacy of SLE66 on AD Skin Symptoms
The synthesized pseudo ceramide (hexadecyl p-hydroxyethyl palmitic amide (SLE66)) has two long alkyl chains and a structure with amide bonds and hydroxyl groups as hydrophilic units. The analysis of the properties of alkyl chains indicates that there are saturated straight alkyl chains in SC with structural characteristics very similar to natural ceramides, and there is no unsaturated or methylated branching, which is necessary to form a multi lipid bilayer in SC. Differential scanning calorimetry and X-ray analysis indicate that the stable α-configuration of this ceramide structure has a lamellar structure containing fatty acids and cholesterol. Topical application of this compound significantly restores the skin's water-retaining capacity while improving dryness caused by solvent treatments.
What is the product name of CAS number 110483-07-3?
The product name is Cetyl-PG hydroxyethyl palmitamide.
What is the molecular weight of Cetyl-PG hydroxyethyl palmitamide?
The molecular weight is 598.
What is the molecular formula of Cetyl-PG hydroxyethyl palmitamide?
The molecular formula is C37H75NO4.
What is the physical state of Cetyl-PG hydroxyethyl palmitamide?
It is in a solid physical state.
What are the typical applications of Cetyl-PG hydroxyethyl palmitamide?
It can be used as an emulsifying agent, dispersing agent, solubilizing agent, antirust agent, and anticorrosive agent.
What percentage of actives does Cetyl-PG hydroxyethyl palmitamide contain?
It contains 95% actives.
What are some synonyms for Cetyl-PG hydroxyethyl palmitamide?
Some synonyms include Hydroxyethyl palmityl oxyhydroxypropyl palmitamide and Hexadecanamide, N-(2-hydroxyethyl)-N-(3-hexadecyloxy-2-hydroxypropyl)-.
What are the key properties of Cetyl-PG hydroxyethyl palmitamide?
It is an effective emulsifying, dispersing, and solubilizing agent with antirust and anticorrosive properties.
How can Cetyl-PG hydroxyethyl palmitamide be used in industrial applications?
It can be used to stabilize emulsions, disperse ingredients, improve solubility, and protect against rust and corrosion in various industrial processes.
What is the significance of the CAS number 110483-07-3?
The CAS number is used to uniquely identify Cetyl-PG hydroxyethyl palmitamide in chemical databases and ensure accurate referencing in research and industrial applications.
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