Arduino, Ilaria, et al. Acta biomaterialia 121 (2021): 566-578.
Multiple studies have shown that using solid lipid nanoparticles (SLN) as colloidal drug delivery systems offers more advantages compared to lipid emulsions, liposomes, and polymeric nanoparticles. SLNs possess numerous benefits inherent to various nanosystems while eliminating many of their disadvantages.
Production of SLN
To produce SLNs, 60 mg of cetyl palmitate and 12 mg of 16:0 PEG-2-PE are co-dissolved in 1 mL of chloroform. This mixture is gently stirred to achieve a homogeneous solution, which is then gradually added dropwise to an aqueous solution containing 2% w/v Pluronic F68 (3 mL of ultrapure water) at a temperature of 65 °C. The mixture is then sonicated using an ultrasonic probe tip (0.27 W) for 15 minutes. The organic phase is quickly evaporated using a rotary evaporator at 65 °C. The aqueous solution is left at room temperature for 2 hours to facilitate the complete evaporation of the organic solvent, followed by cooling at 4 °C for 15 minutes to form the SLNs. The resulting SLNs are carefully purified to remove surfactants and residual solvents by ultrafiltration with ultrapure water using a centrifugal filter unit (Centricon Centriplus YM100) at 800 g for 1 hour at 4 °C. The nanocarrier formulation is maintained in ultrapure water at 4 °C.
Teeranachaideekul, Veerawat, et al. European Journal of Pharmaceutics and Biopharmaceutics 67.1 (2007): 141-148.
Nanostructured lipid carriers (NLC) composed of cetyl palmitate and varying amounts of caprylic/capric triglyceride (as liquid lipid) were prepared, with Coenzyme Q10 (Q10) being incorporated into these carriers due to its high lipophilicity.
Preparation of NLC
NLCs containing 24% Q10 (based on lipid content) and NLCs without Q10 were produced using hot high-pressure homogenization (HPH). Briefly, the molten lipid phase containing the solid lipid (cetyl palmitate), liquid lipid, and active ingredient was dispersed into a hot surfactant solution (85 °C) using Ultra-Turrax T25 at 8000 rpm for 1 minute to obtain a pre-emulsion. The hot pre-emulsion was further processed through HPH, applying three homogenization cycles at 500 bar and 85 °C. The lipid dispersion was then cooled to room temperature and solidified under ambient conditions to obtain the aqueous NLC dispersion.
Girardon, Maxime, et al. Journal of Molecular Liquids 308 (2020): 113040.
The interfacial behavior of the model anti-inflammatory drug curcumin in combination with cetyl palmitate and 1,2-dioleoyl-sn-glycero-3-phosphocholine was investigated. Cetyl palmitate can be utilized for topical delivery via nanostructured lipid carriers, while phosphatidylcholine can serve as a component of the carrier and as a model membrane lipid. In this study, surface pressure, thermodynamics, Brewster angle microscopy, molecular dynamics, and polarization-modulated infrared reflection-absorption spectroscopy were employed to better understand the interactions between the delivery system components and their interactions with biological membranes. Additionally, the impact of curcumin on these lipid systems, especially on the model membranes, was analyzed thermodynamically.
The results indicated that a mixture of curcumin and cetyl palmitate could form a Langmuir film, while neither of the pure components alone could achieve this. This effect was explained by the formation of a complex between curcumin and the hydrophobic, water-insoluble cetyl palmitate. The hydrophilic-hydrophobic balance of the complex allows it to penetrate the monolayer and mix with the phospholipids. This finding could be beneficial for the further design of plant-based lipids for drug delivery applications.
What is the CAS number for Cetyl palmitate?
The CAS number for Cetyl palmitate is 540-10-3.
What are some synonyms for Cetyl palmitate?
Some synonyms for Cetyl palmitate are Hexadecanoic acid, hexadecyl ester; n-Hexadecyl hexadecanoate; Palmitic acid, hexadecyl ester.
What is the IUPAC name of Cetyl palmitate?
The IUPAC name of Cetyl palmitate is Hexadecyl hexadecanoate.
What is the molecular weight of Cetyl palmitate?
The molecular weight of Cetyl palmitate is 480.85.
What is the molecular formula of Cetyl palmitate?
The molecular formula of Cetyl palmitate is C32H64O2.
What is the SMILES notation for Cetyl palmitate?
The SMILES notation for Cetyl palmitate is CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC.
What is the InChI Key for Cetyl palmitate?
The InChI Key for Cetyl palmitate is InChI=1S/C32H64O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-34-32(33)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-31H2,1-2H3.
What is the boiling point of Cetyl palmitate?
The boiling point of Cetyl palmitate is 360 °C.
What is the melting point of Cetyl palmitate?
The melting point of Cetyl palmitate is 55-56 °C.
What are some typical applications of Cetyl palmitate?
Some typical applications of Cetyl palmitate include its use as a lubricant, dispersing agent, and emulsion stabilizer.
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